Steven P. Kleopoulos

Icahn School of Medicine at Mount Sinai — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.8kcitations52works34.12yr avg
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Research Topics

Epigenetics and DNA Methylation(12), Genomics and Chromatin Dynamics(11), Genetic Associations and Epidemiology(8), RNA Research and Splicing(8), Bioinformatics and Genomic Networks(8)

Publications49 total

Dynamic Alterations in the Blood Transcriptome Characterize Drug Use Behavior and Co‐Morbidities in Cocaine Use Disorder: A Preliminary Study
European Journal of Neuroscience·2026
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development
Nature Neuroscience·2025· 1 citedOpen Access
Alzheimer’s disease transcriptional landscape in ex vivo human microglia
Nature Neuroscience·2025· 3 cited
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Nature Genetics·2025· 15 cited
Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder
2024Open Access
Massively parallel characterization of regulatory elements in the developing human cortex
Science·2024· 55 citedOpen Access
Genetic regulation of cell type–specific chromatin accessibility shapes brain disease etiology
Science·2024· 35 cited
Single-cell multi-cohort dissection of the schizophrenia transcriptome
Science·2024· 108 citedOpen Access
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders
Science Translational Medicine·2024· 19 citedOpen Access
Alzheimer's disease transcriptional landscape in ex-vivo human microglia
2024· 1 citedOpen Access
Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing
2023· 5 citedOpen Access
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s Disease
2023· 15 citedOpen Access
Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome
Nucleic Acids Research·2023· 25 citedOpen Access
The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development
2023· 5 citedOpen Access
The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development
2023· 4 citedOpen Access
Neuronal, glial and microglial maps of epigenetic and transcriptomics dysregulations in Alzheimer’s disease
Alzheimer s & Dementia·2023· 1 citedOpen Access
Genetic regulation of cell-type specific chromatin accessibility shapes the etiology of brain diseases
2023· 7 citedOpen Access
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations
Nature Genetics·2023· 66 citedOpen Access
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease
Nature Neuroscience·2022· 61 citedOpen Access
Population-level variation in enhancer expression identifies disease mechanisms in the human brain
Nature Genetics·2022· 49 citedOpen Access
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Frequent Co-authors

John F. Fullard(24), Charles V. Mobbs(22), Panos Roussos(21), Jaroslav Bendl(20), Vahram Haroutunian(19), Gabriel E. Hoffman(18), Kiran Girdhar(15), Donald W. Pfaff(14), Pengfei Dong(12), Samir Rahman(11), Toshiya Funabashi(11), Georgios Voloudakis(11), Ruth Misir(11), Biao Zeng(10), Zhiping Shao(10), Roman Kosoy(9), Kristen Brennand(8), Philip J. Brooks(7), Sarah Reach(7), Tooru M. Mizuno(6)