Gabriel E. Hoffman

Allen Institute for Brain Science — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index15.6kcitations213works13.52yr avg
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Research Topics

Genetic Associations and Epidemiology(57), Epigenetics and DNA Methylation(37), Bioinformatics and Genomic Networks(33), Single-cell and spatial transcriptomics(31), Neuroinflammation and Neurodegeneration Mechanisms(26)

Publications207 total

The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development
Nature Neuroscience·2025· 1 citedOpen Access
Sex Differences in Brain Cell Type–Specific Chromatin Accessibility in Schizophrenia
Biological Psychiatry·2025
MULTI-ANCESTRY FINE-MAPPING REVEALS BIPOLAR DISORDER RISK GENES AND HIGHLIGHTS DRUG REPURPOSING OPPORTUNITIES
European Neuropsychopharmacology·2025
Fast Probabilistic Whitening Transformation for Ultra-High Dimensional Genetic Data
2025Open Access
Alzheimer’s disease transcriptional landscape in ex vivo human microglia
Nature Neuroscience·2025· 3 cited
A Transcriptomic Roadmap of Parkinson’s Disease Progression at Single Cell Resolution
2025· 1 citedOpen Access
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
UNC Libraries·2025Open Access
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Utrecht University Repository (Utrecht University)·2025Open Access
Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution
Scientific Data·2025· 7 citedOpen Access
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Nature Genetics·2025· 15 cited
Fast, flexible analysis of differences in cellular composition with crumblr
2025Open Access
Multiomic single-cell profiling identifies critical regulators of postnatal brain
Nature Genetics·2025· 9 cited
Fast, flexible analysis of differences in cellular composition with crumblr
2025· 3 citedOpen Access
A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19
2025Open Access
Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human Brain
2024Open Access
Neuropsychiatric polygenic scores are weak predictors of professional categories
Nature Human Behaviour·2024· 1 citedOpen Access
A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping
Nature Communications·2024· 3 citedOpen Access
Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.
2024Open Access
A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution
2024· 6 citedOpen Access
Single-nucleus transcriptome-wide association study of human brain disorders
2024· 2 citedOpen Access
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Frequent Co-authors

Panos Roussos(31), Kiran Girdhar(22), Jaroslav Bendl(22), John F. Fullard(21), Schahram Akbarian(19), Vahram Haroutunian(16), Kristen Brennand(16), Mette A. Peters(14), Barbara K. Lipska(13), Chang-Gyu Hahn(12), Nancy Francoeur(12), Mads E. Hauberg(12), Bibi Kassim(11), Andrew Chess(11), Leonardo Collado‐Torres(10), Yan Jiang(10), David A. Lewis(10), Eric E. Schadt(10), Laura Sloofman(10), Michael J. Gandal(9)