Zhengxian Gu

WuXi AppTec (China) — China

Medicine · Health Sciences

25h-index2.4kcitations55works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

HIV/AIDS drug development and treatment(38), HIV Research and Treatment(34), HIV/AIDS Research and Interventions(15), Hepatitis C virus research(11), Biochemical and Molecular Research(8)

Publications55 total

Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential
Bioorganic & Medicinal Chemistry·2023· 1 citedOpen Access
Inhibition of the HERG Potassium Ion Channel by Different Non-Nucleoside Human Cytomegalovirus Polymerase Antiviral Templates and the Exploration of Variations of a Pyrroloquinoline Series to Reduce Cardiotoxicity Potential
SSRN Electronic Journal·2023Open Access
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection
Bioorganic & Medicinal Chemistry Letters·2022· 7 citedOpen Access
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability
Journal of Medicinal Chemistry·2021· 103 citedOpen Access
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent
Bioorganic & Medicinal Chemistry·2020· 8 cited
Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor
Antimicrobial Agents and Chemotherapy·2019· 4 citedOpen Access
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease
Bioorganic & Medicinal Chemistry Letters·2018· 3 citedOpen Access
Correction to “The Discovery of 3,3′-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection”
ACS Medicinal Chemistry Letters·2018Open Access
Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection
ACS Medicinal Chemistry Letters·2018· 51 citedOpen Access
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-<i>c</i>]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment
ACS Medicinal Chemistry Letters·2017· 23 citedOpen Access
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD
ACS Medicinal Chemistry Letters·2017· 21 citedOpen Access
Identification of benzazole compounds that induce HIV-1 transcription
PLoS ONE·2017· 3 citedOpen Access
Discovery and Assessment of Atropisomers of (±)-Lesinurad
ACS Medicinal Chemistry Letters·2017· 62 citedOpen Access
PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally
Antimicrobial Agents and Chemotherapy·2016· 2 citedOpen Access
Design, synthesis, and biological evaluation of anti-EV71 agents
Bioorganic & Medicinal Chemistry Letters·2016· 16 cited
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B
Bioorganic & Medicinal Chemistry Letters·2015· 16 cited
HIV Drug Resistance: Molecular Basis and Clinical Significance
2015· 1 cited
6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B
Bioorganic & Medicinal Chemistry Letters·2015· 14 cited
Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B
Journal of Medicinal Chemistry·2013· 43 citedOpen Access
Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein
Antimicrobial Agents and Chemotherapy·2013· 19 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Mark A. Wainberg(22), Michael A. Parniak(10), Joseph M. Colacino(10), Jason D. Graci(9), Horacio Salomón(7), Marla Weetall(7), Gary M. Karp(7), Qing Gao(6), Eric J. Arts(6), M A Wainberg(6), Shu‐Hui Chen(6), Haiying He(6), Neil G. Almstead(6), Frederick Lahser(6), Fusen Lin(5), Anthony Turpoff(5), Guangming Chen(5), Stephen P. Jung(5), Amin A. Nomeir(5), Yudong Quan(4)