Joseph M. Colacino

PTC Therapeutics (United States) — United States

Medicine · Health Sciences

31h-index4.5kcitations100works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(22), Biochemical and Molecular Research(22), Hepatitis C virus research(20), Hepatitis B Virus Studies(17), HIV Research and Treatment(11)

Publications100 total

Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Frontiers in Oncology·2022· 13 citedOpen Access
Small molecule splicing modifiers with systemic HTT-lowering activity
Nature Communications·2021· 83 citedOpen Access
I01 Orally bioavailable small molecule splicing modifiers with systemic and even htt-lowering activity in vitro and in vivo
2021
Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
Molecular Cancer Therapeutics·2021· 21 citedOpen Access
Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human
Drug Metabolism and Pharmacokinetics·2021· 3 citedOpen Access
In vitro cytochrome P450‐ and transporter‐mediated drug interaction potential of 6β‐hydroxy‐21‐desacetyl deflazacort—A major human metabolite of deflazacort
Pharmacology Research & Perspectives·2021· 3 citedOpen Access
Pharmacokinetics and Safety of PTC596, a Novel Tubulin‐Binding Agent, in Subjects With Advanced Solid Tumors
Clinical Pharmacology in Drug Development·2021· 21 cited
The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
Virus Research·2020· 70 citedOpen Access
Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort
Pharmacology Research & Perspectives·2020· 3 citedOpen Access
The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
2020· 7 citedOpen Access
In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren
Pharmacology Research & Perspectives·2020· 13 citedOpen Access
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential
PLoS ONE·2018· 38 citedOpen Access
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Molecular Cancer Therapeutics·2018· 77 cited
PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells
Blood·2017· 3 cited
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Frequent Co-authors

Marla Weetall(17), Neil G. Almstead(11), Stuart W. Peltz(11), Kirk A. Staschke(11), Gary M. Karp(9), Young‐Choon Moon(9), Jason D. Graci(9), Anthony Turpoff(7), Josephine Sheedy(7), Zhengxian Gu(7), Christopher R. Trotta(6), Guangming Chen(6), Jean Hedrick(6), Nicole Risher(6), Ellen Welch(5), Hongyu Ren(5), John Babiak(5), Nanjing Zhang(5), Ronald Kong(5), Liangxian Cao(5)