Josephine Sheedy

Pfeiffer Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.2kcitations53works10.02yr avg
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Research Topics

Biochemical and Molecular Research(15), Cancer, Hypoxia, and Metabolism(13), RNA modifications and cancer(13), Microtubule and mitosis dynamics(7), Pancreatic and Hepatic Oncology Research(5)

Publications53 total

Preclinical studies of gene replacement therapy for CDKL5 deficiency disorder
Molecular Therapy·2024· 10 citedOpen Access
Discovery and SAR Studies of Potent Modulators of BMI‐1 Expression
Helvetica Chimica Acta·2023Open Access
Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Excel file-1 from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Data from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
2023Open Access
Supplementary Figures 1 - 7 from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
Data from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
Data from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
Supplementary Figures 1 - 7 from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
Supplementary Methods from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
Supplementary Methods from Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
2023Open Access
SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor
European Journal of Medicinal Chemistry·2022· 3 citedOpen Access
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Frontiers in Oncology·2022· 13 citedOpen Access
Inhibition of <i> De Novo</i> Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress
Blood·2021
AML-284: Emvododstat (PTC299) Targets De Novo Pyrimidine Synthesis in Acute Myeloid Leukemia
Clinical Lymphoma Myeloma & Leukemia·2021
Poster: AML-284: Emvododstat (PTC299) Targets De Novo Pyrimidine Synthesis in Acute Myeloid Leukemia
Clinical Lymphoma Myeloma & Leukemia·2021
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression
Human Molecular Genetics·2021· 10 cited
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Frequent Co-authors

Marla Weetall(48), Liangxian Cao(22), Young‐Choon Moon(17), Joseph M. Colacino(15), Neil G. Almstead(15), Anna Mollin(15), Nicole Risher(14), Arthur Branstrom(13), Bansri Furia(12), Stuart W. Peltz(11), Ronald Kong(10), Ellen Welch(10), Jean Hedrick(10), Jana Narasimhan(9), John Babiak(9), Thomas W. Davis(9), Christopher R. Trotta(9), Min Jung Kim(9), Tamil Arasu(9), William Lennox(9)