Melissa S. Jurica

University of California, Santa Cruz — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index4.6kcitations89works0.82yr avg
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Research Topics

RNA Research and Splicing(57), RNA and protein synthesis mechanisms(48), RNA modifications and cancer(36), Synthetic Organic Chemistry Methods(9), Genomics and Chromatin Dynamics(6)

Publications89 total

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators
ACS Chemical Biology·2026Open Access
A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators
2025Open Access
The human branchpoint-interacting stem loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and transcriptome
2025Open Access
SF3B1 thermostability as an assay for splicing inhibitor interactions
Journal of Biological Chemistry·2024· 3 citedOpen Access
Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain
RNA·2023· 12 citedOpen Access
Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain
2023· 1 citedOpen Access
A model for DHX15 mediated disassembly of A-complex spliceosomes
RNA·2022· 33 citedOpen Access
U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors
PLoS ONE·2021· 3 citedOpen Access
Chemical probing of U2 snRNA - Capillary electrophoresis chromatograms
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Chemical probing of U2 snRNA - Capillary electrophoresis chromatograms
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
A Model for DHX15 Mediated Disassembly of A-Complex Spliceosomes
2021· 2 citedOpen Access
CCDC 1981585: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 1981586: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
Nature Communications·2021· 62 citedOpen Access
U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors
2021Open Access
Abstract 1832: Development of a splicing modulator-based ADC payload class with immune stimulatory properties for cancer therapy
Cancer Research·2021
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors
Journal of Natural Products·2021· 15 citedOpen Access
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
Cell chemical biology·2021· 37 citedOpen Access
Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing
ACS Chemical Biology·2021· 11 citedOpen Access
Design and synthesis of herboxidiene derivatives that potently inhibit <i>in vitro</i> splicing
Organic & Biomolecular Chemistry·2021· 5 citedOpen Access
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Frequent Co-authors

Arun K. Ghosh(13), Kerstin A. Effenberger(10), Barry Stoddard(7), Melissa J. Moore(6), Beth E. Prichard(5), Raymond J. Monnat(4), Veronica K. Urabe(4), Robert J. Chalkley(4), Alma L. Burlingame(4), Andrew J. MacRae(4), Walter M. Bray(3), Nianchun Ma(3), Anne M. Veitschegger(3), Guddeti Chandrashekar Reddy(3), Andrew D. Mesecar(2), Barry Stoddard(2), Nikolaus Grigorieff(2), K.E. Flick(2), Christopher R. Brown(2), Hinrich Boeger(2)