Melissa J. Moore

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

78h-index24.1kcitations167works37.52yr avg
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Research Topics

RNA Research and Splicing(104), RNA and protein synthesis mechanisms(92), RNA modifications and cancer(76), RNA Interference and Gene Delivery(13), CRISPR and Genetic Engineering(10)

Publications166 total

Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay
Cell Reports·2024· 62 citedOpen Access
Translation-dependent and -independent mRNA decay occur through mutually exclusive pathways defined by ribosome density during T cell activation
Genome Research·2024· 13 citedOpen Access
Tailor made: the art of therapeutic mRNA design
Nature Reviews Drug Discovery·2023· 111 cited
Functional mRNA delivery to hematopoietic stem and progenitor cells <i>in vivo</i>
2022· 1 citedOpen Access
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts
Nature Biotechnology·2022· 201 citedOpen Access
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
Molecular Therapy — Nucleic Acids·2022· 52 citedOpen Access
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
Journal of Controlled Release·2021· 320 citedOpen Access
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways
Genome biology·2021· 26 citedOpen Access
Additional file 3 of Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways
Figshare·2021Open Access
Additional file 2 of Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways
Figshare·2021Open Access
Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation
2020· 2 citedOpen Access
MassTERi: Promoting Translational Research and Entrepreneurship at the University of Massachusetts Medical School
2020Open Access
Mid-gestation Angiogenic Biomarker Levels are Increased in Women at High Risk for Preeclampsia
2020· 1 citedOpen Access
IUBMB Special Jubilee Lecture 2
2020
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways
2019· 1 citedOpen Access
mRNA structure regulates protein expression through changes in functional half-life
Proceedings of the National Academy of Sciences·2019· 532 citedOpen Access
Free circular introns with an unusual branchpoint in neuronal projections
eLife·2019· 18 citedOpen Access
Author response: Free circular introns with an unusual branchpoint in neuronal projections
2019· 1 citedOpen Access
Free circular introns with an unusual branchpoint in neuronal projections
2019Open Access
RNA and DNA Integrity Remain Stable in Frozen Tissue After Long-Term Storage at Cryogenic Temperatures: A Report from the Ontario Tumour Bank
Biopreservation and Biobanking·2019· 41 citedOpen Access
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Frequent Co-authors

Alper Küçükural(4), Emiliano P. Ricci(4), Ajit Nott(4), Katherine A. Fitzgerald(3), Melissa S. Jurica(3), Hervé Le Hir(3), Phillip A. Sharp(3), Zhiping Weng(3), Phillip D. Zamore(3), Charles C. Query(3), Thomas Ø Tange(3), Manuel Garber(2), Susan Carpenter(2), Maninjay Atianand(2), Pallavi Gandhi(2), Daniel R. Caffrey(2), Kimberly J. Hassett(2), Angela Woods(2), Iain J. McFadyen(2), Örn Almarsson(2)