Michael R. Hayden

University of British Columbia — Canada

Neuroscience · Life Sciences

146h-index86.4kcitations1.1kworks3.22yr avg
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Research Topics

Genetic Neurodegenerative Diseases(520), Mitochondrial Function and Pathology(291), Neurological disorders and treatments(167), Lipid metabolism and disorders(113), Cholesterol and Lipid Metabolism(97)

Publications1.1k total

Long-Term Slowing of Progression in Huntington’s Disease with Pridopidine Treatment
2026Open Access
Sequence Variants in Small CAG Repeat Expansions of the <i>HTT</i> Gene and Disease Onset and Progression in Huntington Disease
Neurology·2025· 1 citedOpen Access
Pridopidine treatment in ALS: subgroup analyses from the HEALEY ALS Platform trial
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration·2025· 1 citedOpen Access
Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases
Pharmaceuticals·2025· 1 citedOpen Access
Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters
PLoS ONE·2025Open Access
Age, Chemistry, and Kinematics of the Inner Galaxy Revealed by MUSE
arXiv (Cornell University)·2025Open Access
Sigma-2 Receptor Antagonism Enhances the Neuroprotective Effects of Pridopidine, a Sigma-1 Receptor Agonist, in Huntington’s Disease
Molecular Neurobiology·2025
The GECKOS survey: The formation history of a barred galaxy via structural decomposition and spatially resolved spectroscopy
Astronomy and Astrophysics·2025Open Access
The GECKOS Survey: resolved, multiphase observations of mass loading and gas density in the galactic wind of NGC 4666
Monthly Notices of the Royal Astronomical Society·2025Open Access
Antidopaminergic Medications Are Associated with Faster Decline in Measures of Clinical Outcome in HD: Insights from PROOF-HD
2025· 1 citedOpen Access
The GECKOS survey: Jeans anisotropic models of edge-on discs uncover the impact of dust and kinematic structures
Astronomy and Astrophysics·2025Open Access
Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease
Molecular Therapy — Nucleic Acids·2025Open Access
Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial
Nature Medicine·2025· 5 citedOpen Access
The GECKOS survey: Identifying kinematic sub-structures in edge-on galaxies
Astronomy and Astrophysics·2025· 13 citedOpen Access
In the phase 3 PROOF-HD trial, pridopidine shows consistent motor function improvements in Q-Motor measures, supporting Q-Motor as a predictive measure of long-term functional benefit and slower progression (cUHDRS) in Huntington disease
Neurotherapeutics·2025Open Access
Pridopidine treatment benefits in definite, probable, and early (&lt;18mo onset) subjects with ALS in the HEALEY ALS Platform Trial
Neurotherapeutics·2025Open Access
Peripheral Artery Disease: Atherosclerosis, Decreased Nitric Oxide, and Vascular Arterial Stiffening
Journal of Vascular Diseases·2025· 1 citedOpen Access
Reduced Palmitoylation of <scp>SQSTM1</scp> /p62 in Huntington Disease Is Associated With Impaired Autophagy
The FASEB Journal·2025· 6 citedOpen Access
Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification
Biomarker Research·2025· 1 citedOpen Access
Pridopidine for the Treatment of ALS–Improvements in the Subgroup of Definite, Probable, and Early (&lt;18mo from Onset) Subjects in the Phase 2 Healey ALS Platform Trial (S5.010)
Neurology·2025
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Frequent Co-authors

Blair R. Leavitt(10), Rona K. Graham(9), Cheryl L. Wellington(9), Roshni R. Singaraja(7), Donald W. Nicholson(6), Y. Paul Goldberg(5), Sophie Roy(5), Mahmoud A. Pouladi(5), Jane Theilmann(5), Elena Cattaneo(4), Michael A. Kalchman(4), Marie‐Pierre Dubé(4), Jamal Nasir(4), Jutta Zeisler(4), Krista McCutcheon(4), Jane S. Paulsen(4), Lisa Ellerby(4), Abigail S. Hackam(4), Dale E. Bredesen(4), Linhua Zhang(3)