Jean‐Christophe Jonas

UCLouvain — Belgium

Medicine · Health Sciences

47h-index8.2kcitations142works0.02yr avg
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Research Topics

Pancreatic function and diabetes(107), Diabetes and associated disorders(39), Metabolism, Diabetes, and Cancer(28), Endoplasmic Reticulum Stress and Disease(24), Diet, Metabolism, and Disease(23)

Publications140 total

Pan-fibrotic gene expression signature in major chronic diseases by integrative bulk and single-cell transcriptomic analyses
2025Open Access
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
Diabetologia·2022· 13 citedOpen Access
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo
Frontiers in Cell and Developmental Biology·2022· 41 citedOpen Access
The lack of functional nicotinamide nucleotide transhydrogenase only moderately contributes to the impairment of glucose tolerance and glucose-stimulated insulin secretion in C57BL/6J vs C57BL/6N mice
Diabetologia·2021· 21 citedOpen Access
Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure
The FASEB Journal·2021· 9 citedOpen Access
Non-canonical mitochondrial STAT3 signaling mediates exercise-induced insulin secretion down-regulation
2021Open Access
Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response
Biology·2021· 23 citedOpen Access
Inhibition of the water channel aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide
European Heart Journal·2020· 5 citedOpen Access
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide
Science Translational Medicine·2020· 78 citedOpen Access
Aspalathin Protects Insulin‐Producing β Cells against Glucotoxicity and Oxidative Stress‐Induced Cell Death
Molecular Nutrition & Food Research·2020· 33 citedOpen Access
Proof-of-concept for 2D/CT element analysis of entire cryofrozen islets of Langerhans using a cryoloop synchrotron X-ray fluorescence setup
Journal of Analytical Atomic Spectrometry·2020· 7 citedOpen Access
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
JCI Insight·2019· 72 citedOpen Access
Editorial Overview: “Islet Biology in Type 2 Diabetes”
Journal of Molecular Biology·2019Open Access
Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells
Journal of Molecular Biology·2019· 75 cited
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans
Diabetologia·2019· 25 citedOpen Access
Phlda3 regulates beta cell survival during stress
Scientific Reports·2019· 29 citedOpen Access
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
Nucleic Acids Research·2018· 139 citedOpen Access
Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers
Diabetes·2018· 44 citedOpen Access
Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis
Journal of Molecular Endocrinology·2018· 40 citedOpen Access
Glucose Acutely Reduces Cytosolic and Mitochondrial H <sub>2</sub> O <sub>2</sub> in Rat Pancreatic Beta Cells
Antioxidants and Redox Signaling·2018· 24 citedOpen Access
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Frequent Co-authors

Patrick Gilon(13), Jean‐Claude Henquin(10), D. Ross Laybutt(8), Mohammed Bensellam(7), J. C. Henquin(6), Yves Guiot(6), Décio L. Eizirik(5), Gordon C. Weir(5), Magalie A. Ravier(5), Miriam Cnop(4), Arun Sharma(4), Wendy Hasenkamp(4), Susan Bonner‐Weir(4), Myriam Nenquin(4), Frans Schuit(4), Letícia Prates Roma(4), Garry M. Steil(3), H. Elouil(3), Piero Marchetti(3), Mariana Igoillo‐Esteve(3)