Anthony Schwacha

University of Pittsburgh — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index3.0kcitations26works0.02yr avg
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Research Topics

DNA Repair Mechanisms(17), Bacterial Genetics and Biotechnology(9), DNA and Nucleic Acid Chemistry(7), Fungal and yeast genetics research(4), Photosynthetic Processes and Mechanisms(3)

Publications26 total

An improved cytological assay for R-loop detection in <i>Saccharomyces cerevisiae</i> utilizing a catalytically inactive RNase H
G3 Genes Genomes Genetics·2025Open Access
A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics
SLAS DISCOVERY·2019· 8 citedOpen Access
A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M
PLoS Genetics·2016· 35 citedOpen Access
Strand separation unravelled
Nature·2015· 7 citedOpen Access
Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate
Molecular and Cellular Biology·2015· 16 citedOpen Access
The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target
BioMed Research International·2014· 73 citedOpen Access
Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase
Bioscience Reports·2013· 51 citedOpen Access
The Eukaryotic Mcm2-7 Replicative Helicase
Sub-cellular biochemistry/Subcellular biochemistry·2012· 53 cited
The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’
Nucleic Acids Research·2010· 61 citedOpen Access
The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase
Microbiology and Molecular Biology Reviews·2009· 328 citedOpen Access
Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability
Molecular and Cellular Biology·2008· 118 citedOpen Access
The Mcm2-7 Complex Has In Vitro Helicase Activity
Molecular Cell·2008· 290 citedOpen Access
Differences in the Single-stranded DNA Binding Activities of MCM2-7 and MCM467
Journal of Biological Chemistry·2007· 80 citedOpen Access
Interactions between Two Catalytically Distinct MCM Subgroups Are Essential for Coordinated ATP Hydrolysis and DNA Replication
Molecular Cell·2001· 193 cited
Interhomolog Bias during Meiotic Recombination: Meiotic Functions Promote a Highly Differentiated Interhomolog-Only Pathway
Cell·1997· 470 citedOpen Access
Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes.
Proceedings of the National Academy of Sciences·1996· 175 citedOpen Access
Identification of double holliday junctions as intermediates in meiotic recombination
Cell·1995· 490 citedOpen Access
Identification of the hutUH operator (hutUo) from Klebsiella aerogenes by DNA deletion analysis
Journal of Bacteriology·1994· 13 citedOpen Access
Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis
Cell·1994· 384 cited
The nac (nitrogen assimilation control) gene from Klebsiella aerogenes
Journal of Bacteriology·1993· 41 citedOpen Access
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Frequent Co-authors

Matthew L. Bochman(7), R. Bender(5), Nancy Kleckner(4), Sriram Vijayraghavan(3), Stephen P. Bell(2), Nicholas W. Simon(2), Feng-Ling Tsai(2), A Storlazzi(1), Li Xu(1), Sandlin P. Seguin(1), Jeffrey L. Brodsky(1), William Seibel(1), Joseph A. Prinz(1), Heather K. MacAlpine(1), David M. MacAlpine(1), Patrick Oriel(1), R Osuna(1), Jill A. Cohen(1), Kalle Gehring(1), Marilyn Ngo(1)