Daniel M. Rosenbaum

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index20.2kcitations167works3.52yr avg
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Research Topics

Receptor Mechanisms and Signaling(37), Neuroscience and Neuropharmacology Research(21), Sleep and Wakefulness Research(18), Neuropeptides and Animal Physiology(15), Neuroinflammation and Neurodegeneration Mechanisms(13)

Publications164 total

Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) therapy for patients with advanced cancer: protocol for a multi-method feasibility trial
Pilot and Feasibility Studies·2025Open Access
Structural mechanism of CB1R binding to peripheral and biased inverse agonists
Nature Communications·2024· 6 citedOpen Access
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 <i>in vivo</i>
mBio·2024· 4 citedOpen Access
Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines
Bioorganic & Medicinal Chemistry Letters·2024· 4 cited
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo
2023· 1 citedOpen Access
Reply to: The G protein preference of orexin receptors is currently an unresolved issue
Nature Communications·2023Open Access
Molecular mechanism of fatty acid activation of FFAR1
Proceedings of the National Academy of Sciences·2023· 32 citedOpen Access
Orexin A, an amphipathic α-helical neuropeptide involved in pleiotropic functions in the nervous and immune systems: Synthetic approach and biophysical studies of the membrane-bound state
Biophysical Chemistry·2023· 3 citedOpen Access
Evaluation of the efficacy of the hypocretin/orexin receptor agonists <scp>TAK</scp>‐925 and <scp>ARN</scp>‐776 in narcoleptic <scp><i>orexin/tTA; TetO‐DTA</i></scp> mice
Journal of Sleep Research·2023· 7 citedOpen Access
Reversible Vasoconstrictive Syndrome in Pregnancy
2023
Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic <i>Orexin/tTA; TetO-DTA</i> Mice
2022Open Access
Molecular mechanism of the wake-promoting agent TAK-925
Nature Communications·2022· 32 citedOpen Access
Molecular basis for ligand modulation of the cannabinoid CB<sub>1</sub> receptor
British Journal of Pharmacology·2021· 16 citedOpen Access
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
Cell·2021· 31 citedOpen Access
Chicken Scap D435V L1-L7 domain / Fab complex focused map
2021
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Cell·2021· 157 citedOpen Access
Anesthesia for Carotid Endarterectomy
2021
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Proceedings of the National Academy of Sciences·2020· 29 citedOpen Access
Structural and functional diversity calls for a new classification of ABC transporters
FEBS Letters·2020· 273 citedOpen Access
Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor
Journal of Medicinal Chemistry·2020· 11 citedOpen Access
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Frequent Co-authors

Brian K. Kobilka(10), Søren G. F. Rasmussen(8), Sean I. Savitz(8), Pearl S. Rosenbaum(8), William I. Weis(7), Jie Yin(7), Hee‐Jung Choi(6), Manjeet Singh(6), Steven Roth(6), Foon Sun Thian(5), Tong Sun Kobilka(5), Samit Malhotra(4), Zhenhua Shao(4), Gaurav Gupta(4), John A. Kessler(4), Pil Seok Chae(3), Roger K. Sunahara(3), Karen Chapman(3), Lindsay Clark(3), Junmei Wang(3)