Joseph R. Marszalek

The University of Texas MD Anderson Cancer Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index9.7kcitations271works3.62yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(67), PARP inhibition in cancer therapy(25), Acute Myeloid Leukemia Research(24), Melanoma and MAPK Pathways(23), Cancer, Lipids, and Metabolism(23)

Publications271 total

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen
npj Breast Cancer·2025· 1 citedOpen Access
Supplementary Figures 1-4 from Subtype and Site Specific–Induced Metabolic Vulnerabilities in Prostate Cancer
2025Open Access
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence
Nature Communications·2025· 1 citedOpen Access
1299 Tri-specific T cell engager (TCE) targeting cathepsin G peptide-HLA (pHLA) complex with enhanced antileukemic activity via proprietary CD28 co-stimulation
Regular and Young Investigator Award Abstracts·2025Open Access
TRLS-12 PD-1 AND LAG3 COMBINATION BLOCKADE THERAPY REDUCES MELANOMA BRAIN METASTATIC TUMOR GROWTH IN PRECLINICAL MODELS AND IS ABROGATED BY NEUTROPHIL INFILTRATION
Neuro-Oncology Advances·2025Open Access
Abstract 3824: Investigating the role of allelic imbalance in pancreatic cancer aggressiveness, survival, and therapeutic resistance
Cancer Research·2025
Abstract 447: Preclinical development and characterization of IACS-16559, a dual bromodomain inhibitor of CBP/EP300, and its potential in AML subtypes
Cancer Research·2025
Abstract 5167: Development of advanced preclinical models for an in-depth characterization of cardiac angiosarcoma
Cancer Research·2025
Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer
2025· 1 citedOpen Access
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer
mAbs·2024· 1 citedOpen Access
100 (PB088): KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications.
European Journal of Cancer·2024
126 (PB114): A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer
European Journal of Cancer·2024
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Nature Cancer·2024· 36 citedOpen Access
Data from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Supplementary S1-S8 from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Supplementary Table S1 from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Data from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Supplementary S1-S8 from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Supplementary Table S1 from Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
2024Open Access
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
Molecular Cell·2024· 35 citedOpen Access
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Frequent Co-authors

Timothy P. Heffernan(14), Christopher P. Vellano(14), Ningping Feng(12), Giulio Draetta(11), Philip Jones(11), Maria Emilia Di Francesco(10), Christopher A. Bristow(9), Yuting Sun(7), Jason Gay(7), Marina Konopleva(7), Michael Peoples(6), P. Andrew Futreal(6), Yongying Jiang(5), Mikhila Mahendra(5), Carlo Toniatti(5), Sonal Gera(4), John M. Asara(4), Jennifer Bardenhagen(4), Jason B. Cross(4), Barbara Czakó(4)