Colin T. Shearn

Children's Hospital Colorado — United States

Medicine · Health Sciences

27h-index1.9kcitations81works0.92yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(26), Alcohol Consumption and Health Effects(22), Genomics, phytochemicals, and oxidative stress(14), Liver Diseases and Immunity(9), Endoplasmic Reticulum Stress and Disease(7)

Publications81 total

Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes
Frontiers in Endocrinology·2025Open Access
Rapid protein carbonylation and decreased insulin secretion induced by inflammatory oxidative stress compounds
Free Radical Biology and Medicine·2025· 3 cited
Inflammatory Oxidative Stress Compounds Inhibit Insulin Secretion through Rapid Protein Carbonylation
2025Open Access
Abstract 2481 Inhibition of Insulin Secretion Induced by Oxidative Stress Compounds
Journal of Biological Chemistry·2025Open Access
BPS2025 - C2 domains react with malondialdehyde to decrease membrane binding
Biophysical Journal·2025
Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions
Frontiers in Immunology·2025· 1 citedOpen Access
Overexpression of TNFα in TNF∆ARE+/− mice increases hepatic periportal inflammation and alters bile acid signaling in mice
Hepatology Communications·2024· 2 citedOpen Access
Parenteral nutrition results in peripheral ileal to hepatic circadian discordance in mice
American Journal of Physiology-Gastrointestinal and Liver Physiology·2024· 1 citedOpen Access
Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition
PLoS ONE·2023· 4 citedOpen Access
Endocrine pancreas-specific <i>Gclc</i> gene deletion causes a severe diabetes phenotype
2023· 4 citedOpen Access
Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury
Hepatology Communications·2023· 17 citedOpen Access
The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease
PLoS ONE·2022· 8 citedOpen Access
C2 domain lysine clusters are highly susceptible to non-enzymatic post-translational modifications
Biophysical Journal·2022
Interrupting tumor necrosis factor–alpha signaling prevents parenteral nutrition–associated cholestasis in mice
Journal of Parenteral and Enteral Nutrition·2021· 12 cited
Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition–associated cholestasis in mice
Hepatology·2021· 41 cited
NF‐κB Regulation of LRH‐1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition–Associated Cholestasis
Hepatology·2021· 29 citedOpen Access
234 COLOCALIZATION OF AUTOPHAGY AND OXIDATIVE STRESS IN PERIPORTAL HEPATOCYTES IN HUMAN AND MURINE CHOLANGIOPATHIES
Gastroenterology·2021
Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach
Toxicological Sciences·2021· 15 citedOpen Access
Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption
Antioxidants·2021· 5 citedOpen Access
Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin
Journal of Biological Chemistry·2020· 18 citedOpen Access
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Frequent Co-authors

Dennis R. Petersen(28), David J. Orlicky(28), Kristofer S. Fritz(15), Rebecca L. Smathers(9), James J. Galligan(8), Laura Saba(8), James R. Roede(7), Martin J. J. Ronis(7), Philip Reigan(6), Donald S. Backos(6), Edward E. Schmidt(6), Ronald J. Sokol(6), Kelly E. Mercer(6), Kenneth N. Maclean(5), Peter S. Harris(5), Aimee L. Anderson(5), Colin G. Miller(4), Mohammed A. Assiri(4), Michael W. Devereaux(4), Cole R. Michel(4)