Donald S. Backos

University of Colorado Anschutz Medical Campus — United States

Neuroscience · Life Sciences

32h-index6.2kcitations110works4.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuroscience and Neuropharmacology Research(19), Sirtuins and Resveratrol in Medicine(9), Computational Drug Discovery Methods(6), Cancer, Hypoxia, and Metabolism(6), Retinal Development and Disorders(6)

Publications110 total

Endocrine-Disrupting Activities of Flavones on Steroid Receptors: Structural Requirements and Synthesis of Novel Flavone with Improved Estrogenic Activity
Biomedicines·2025· 5 citedOpen Access
Design of Potent Menin–KMT2A Interaction Inhibitors with Improved <i>In Vitro</i> ADME Properties and Reduced hERG Affinity
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors
Molecules·2023Open Access
Novel chromobox 2 inhibitory peptide decreases tumor progression
Expert Opinion on Therapeutic Targets·2023· 8 cited
3063 – A NOVEL MUTATION IN TASPASE1 IMPAIRS FLEXIBILITY AND SUBSTRATE BINDING LEADING TO MARROW FAILURE.
Experimental Hematology·2023
Novel chromobox 2 inhibitory peptide decreases tumor progression
Figshare·2023Open Access
Characterization of a Primordial Major Capsid-Scaffolding Protein Complex in Icosahedral Virus Shell Assembly
Journal of Molecular Biology·2022· 6 cited
10-Alkoxy-anthracenyl-isoxazole analogs have sub-micromolar activity against a Glioblastoma multiforme cell line
Bioorganic & Medicinal Chemistry·2022· 5 cited
Statin therapy inhibits fatty acid synthase via dynamic protein modifications
Nature Communications·2022· 29 citedOpen Access
Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice
Journal of Biological Chemistry·2022· 18 citedOpen Access
Characterization of a Major Capsid-Scaffolding Protein Nucleation Intermediate In Icosahedral Virus Shell Assembly
SSRN Electronic Journal·2022· 1 citedOpen Access
Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data
Data in Brief·2021· 1 citedOpen Access
Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation
ACS Chemical Neuroscience·2021· 3 cited
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors
Bioorganic & Medicinal Chemistry·2021· 9 citedOpen Access
Statin therapy inhibits fatty acid synthase via dynamic protein modifications
2021· 4 citedOpen Access
Maneb adducts human peroxiredoxin 3 through thiol interactions
Advances in Redox Research·2021· 1 citedOpen Access
Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice
American Journal of Respiratory Cell and Molecular Biology·2021· 93 citedOpen Access
Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes
Frontiers in Immunology·2020· 14 citedOpen Access
Computational screening and optimization of small molecules for African sleeping sickness
2020
10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties
Bioorganic & Medicinal Chemistry·2020· 8 citedOpen Access
page 1 of 6Next →

Frequent Co-authors

Philip Reigan(19), Christopher J. Matheson(12), Matthew D. Hirschey(7), Christopher C. Franklin(6), José A. Esteban(6), Colin T. Shearn(6), Kristofer S. Fritz(6), Dennis R. Petersen(6), Kristin A. Anderson(5), Olga Ilkayeva(5), Kimberly A. Casalvieri(5), Gregory R. Wagner(4), Paul A. Grimsrud(4), David J. Orlicky(4), Peter S. Harris(4), Andreas S. Madsen(3), Christian A. Olsen(3), J. Will Thompson(3), Robert D. Stevens(3), Nashaat Z. Gerges(3)