Matthew D. Hirschey

National University of Singapore — Singapore

Medicine · Health Sciences

53h-index17.7kcitations150works1.62yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(61), Adipose Tissue and Metabolism(44), Mitochondrial Function and Pathology(23), Autophagy in Disease and Therapy(23), Biochemical effects in animals(18)

Publications150 total

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mapping
2026Open Access
In vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer
PNAS Nexus·2026Open Access
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia
Nature Metabolism·2025Open Access
Targeting androgen receptor signaling to enhance cancer immunotherapy
Trends in Pharmacological Sciences·2025· 1 citedOpen Access
Cysteine S-acetylation is a widespread post-translational modification on metabolic proteins
npj Metabolic Health and Disease·2025Open Access
Sirtuin-3 Deletion in the Distal Nephron Protects Against Ischemic AKI
Journal of the American Society of Nephrology·2025
GAUDI: interpretable multi-omics integration with UMAP embeddings and density-based clustering
Nature Communications·2025· 6 citedOpen Access
Toward manipulating sex hormones to modulate the adaptive antitumor immune response in liver cancer.
Journal of Clinical Oncology·2025
Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells
PLoS Pathogens·2025· 1 citedOpen Access
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice
2025· 1 citedOpen Access
Pathway Coessentiality Mapping Reveals Complex II is Required for <i>de novo</i> Purine Biosynthesis in Acute Myeloid Leukemia
2025· 1 citedOpen Access
Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells
2024Open Access
Interpretable multi-omics integration with UMAP embeddings and density-based clustering
2024· 2 citedOpen Access
8060 SIRT4 Plays a Role in Mammary Gland Development
Journal of the Endocrine Society·2024Open Access
Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
UNC Libraries·2024· 2 citedOpen Access
Cysteine <i>S</i> -acetylation is a post-translational modification involved in metabolic regulation
2024· 2 citedOpen Access
Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence
Science Advances·2024· 10 citedOpen Access
NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease
Journal of Biological Chemistry·2023· 62 citedOpen Access
In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence
npj Breast Cancer·2022· 13 citedOpen Access
Statin therapy inhibits fatty acid synthase via dynamic protein modifications
Nature Communications·2022· 29 citedOpen Access
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Frequent Co-authors

Eric Verdin(16), Olga Ilkayeva(9), Tadahiro Shimazu(8), Michelle Green(7), Frank K. Huynh(7), Jason W. Locasale(7), Kristin A. Anderson(6), Gregory R. Wagner(6), Christian A. Olsen(6), Bjoern Schwer(5), David B. Lombard(5), Andreas S. Madsen(5), Eoin McDonnell(5), Eric S. Goetzman(4), Robert D. Stevens(4), Frederick W. Alt(4), Donald S. Backos(4), Paul A. Grimsrud(4), Dhaval P. Bhatt(4), Enxuan Jing(3)