Jason W. Locasale

Duke University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

91h-index42.1kcitations431works9.12yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Cancer, Hypoxia, and Metabolism(179), Epigenetics and DNA Methylation(78), Metabolism, Diabetes, and Cancer(61), Metabolomics and Mass Spectrometry Studies(48), RNA modifications and cancer(43)

Publications430 total

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway
UNC Libraries·2025Open Access
Abstract P1-05-02: Medium chain fatty acids shift metabolism towards the de novo serine pathway fostering epigenetic plasticity and oxidative DNA damage
Clinical Cancer Research·2025
Abstract 5402: Metabolic shift towards the <i>de novo</i> serine pathway in non-transformed breast cells drives epigenetic plasticity, oxidative DNA damage, and pro-tumorigenic cChanges associated with aging
Cancer Research·2025
Abstract 4172: Carnitine metabolism regulates ovarian cancer metastasis
Cancer Research·2025
A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells
Science Advances·2025· 5 citedOpen Access
Quantitation of metabolic activity from isotope tracing data using automated methodology
Nature Metabolism·2024· 3 cited
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
Cell Metabolism·2024· 22 citedOpen Access
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
Science·2024· 35 citedOpen Access
Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer
JAMA Network Open·2024· 3 citedOpen Access
eLife Assessment: Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
2024Open Access
Separation of reproductive decline from lifespan extension during methionine restriction
Nature Aging·2024· 8 cited
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
UNC Libraries·2024Open Access
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
UNC Libraries·2024Open Access
Identification of bbox1 as a therapeutic target in triple-negative breast cancer
UNC Libraries·2024Open Access
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo
Communications Biology·2024· 8 citedOpen Access
l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models
Journal of Clinical Investigation·2024· 5 citedOpen Access
Diet and Cancer Metabolism
Cold Spring Harbor Perspectives in Medicine·2024· 9 citedOpen Access
Figure S4 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
2024Open Access
Table S2 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
2024Open Access
Figure S3 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
2024Open Access
page 1 of 22Next →

Frequent Co-authors

Xiaojing Liu(13), Lewis C. Cantley(8), Jeffrey C. Rathmell(8), John M. Asara(7), Matthew G. Vander Heiden(7), Xia Gao(7), Juan Liu(7), Costas A. Lyssiotis(6), Rigel J. Kishton(6), Ziwei Dai(6), Michael A. Reid(6), Andrew N. Macintyre(4), Samantha J. Mentch(4), Sydney M. Sanderson(4), Marc O. Warmoes(4), Maria V. Liberti(3), Ahmad A. Cluntun(3), Valerie A. Gerriets(3), Amanda Nichols(3), Aguirre A. de Cubas(3)