Costas A. Lyssiotis

University of Michigan — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

79h-index31.9kcitations749works1.82yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(265), Glioma Diagnosis and Treatment(148), Pancreatic and Hepatic Oncology Research(120), Epigenetics and DNA Methylation(104), ATP Synthase and ATPases Research(87)

Publications749 total

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression
Nature·2026· 1 citedOpen Access
Lipid Metabolism Transcriptomic Signature of Defective Erythropoiesis in Diamond Blackfan Anemia syndrome
Blood Advances·2026Open Access
Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer
2026Open Access
Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression
2025Open Access
Author Correction: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
Nature·2025Open Access
Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer
2025Open Access
Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia
2025Open Access
Digital twins for in vivo metabolic flux estimations in patients with brain cancer
Cell Metabolism·2025Open Access
A metabolic atlas of mouse aging
Cell Metabolism·2025· 4 cited
Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients
2025Open Access
Reprogramming the Immune Suppressive Tumor Microenvironment in Glioma Enhances the Efficacy of Immune-Mediated Gene Therapy
2025
Cellular senescence in precancer lesions and early-stage cancers
Cancer Cell·2025· 1 cited
Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death
2025Open Access
Supplementary Figure S4 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Supplementary Figure S1 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Supplementary Table S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Supplementary Figure S7 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Data from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Supplementary Figure S2 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
Supplementary Table S3 from Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
2025Open Access
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Frequent Co-authors

Lewis C. Cantley(18), John M. Asara(17), Christopher J. Halbrook(10), Peter Sajjakulnukit(8), Marina Pasca di Magliano(8), Alec C. Kimmelman(7), Daniel M. Kremer(7), Haoqiang Ying(6), Jason W. Locasale(6), Howard C. Crawford(6), Ho‐Joon Lee(5), Li Zhang(5), Zeribe C. Nwosu(5), Eileen S. Carpenter(5), Samantha B. Kemp(5), Timothy L. Frankel(5), Samuel A. Kerk(5), Yatrik M. Shah(5), Nina G. Steele(4), Nupur K. Das(4)