Barbara Renga

University of Perugia — Italy

Medicine · Health Sciences

50h-index8.1kcitations146works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(44), Liver Disease Diagnosis and Treatment(19), Cholesterol and Lipid Metabolism(19), Helicobacter pylori-related gastroenterology studies(17), Estrogen and related hormone effects(13)

Publications146 total

Non invasive prenatal diagnosis of fetal aneuploidy using cell free fetal DNA
European Journal of Obstetrics & Gynecology and Reproductive Biology·2018· 37 cited
Platelets and cardiovascular risk
Acta cardiologica. Supplementum·2017· 29 cited
Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands
Scientific Reports·2016· 16 citedOpen Access
825 BAR502, a Dual FXR and GPBAR1 Agonist, Reverses Steatosis and Fibrosis in Rodent Model of NASH By Modulating Authophagic Genes
Gastroenterology·2016· 1 cited
Sa1587 A Comprehensive Analysis of Small Heterodimer Partner (SHP) Target Genes in Hepatic Stellate Cells and the Discovery of a New Class of SHP Agonists That Reduces Liver Fibrosis
Gastroenterology·2016
Mo1915 Genetic Ablation and Pharmacological Blockade of CCR5 by the anti-HIV Small Molecule Inhibitor Maraviroc Inhibits Leukocyte Trafficking and Protects Against Mucosal Inflammation in Murine Models Colitis
Gastroenterology·2016
Mo1916 BAR 501, a Novel GPBAR1 Ligand, Reverses Intestinal and Liver Inflammatory Models Demonstrating That GPBAR1 Is an Essential Modulator of Innate Immunity in Entero-Hepatic Tissues
Gastroenterology·2016
Tu1828 GPBAR1(TGR5) Is Highly Expressed in Human Gastric Cancers and Its Activation by Selective or GPBAR1/FXR Dual Ligands Promotes Epithelial Mesenchymal Transition and Tumor Spreading
Gastroenterology·2016
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
Scientific Reports·2016· 47 citedOpen Access
BAR501 correct for endtothelial dysfunction caused by methionine diet.
Figshare·2015Open Access
BAR501 regulates the expression of CSE and ET-1 in the CCl<sub>4</sub> model of liver cirrhosis.
Figshare·2015Open Access
Administration of BAR501 exerts a direct vasodilatory activity in the CCl<sub>4</sub> model.
Figshare·2015Open Access
Distinctive histologic features the creeping fat and mesenteric adipose tissue in Crohn's disease patients.
Figshare·2015Open Access
Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity
Steroids·2015· 19 cited
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism
Scientific Reports·2015· 27 citedOpen Access
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1
PLoS ONE·2015· 64 citedOpen Access
The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma
Scientific Reports·2015· 9 citedOpen Access
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling
PLoS ONE·2015· 52 citedOpen Access
Cystathionine γ-lyase, a H<sub>2</sub>S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids
American Journal of Physiology-Heart and Circulatory Physiology·2015· 55 cited
Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa
Journal of Gastroenterology·2015· 31 citedOpen Access
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Frequent Co-authors

Stefano Fiorucci(49), Andrea Mencarelli(35), Eleonora Distrutti(25), Sabrina Cipriani(22), Claudio D’Amore(19), Angela Zampella(16), Maria Valeria D’Auria(8), Elisabetta Antonelli(7), Stefano Orlandi(7), Giuseppe Bifulco(7), Valentina Sepe(7), Maria Chiara Monti(7), Antonio Morelli(6), Franco Baldelli(6), Giuseppe Palladino(6), Roberto Pellicciari(5), Annibale Donini(5), Marco Migliorati(5), Adriana Carino(5), Carmen Festa(5)