Christopher L. McClendon

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index3.5kcitations31works0.02yr avg
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Research Topics

Protein Structure and Dynamics(22), Enzyme Structure and Function(7), Protein Kinase Regulation and GTPase Signaling(6), Computational Drug Discovery Methods(6), RNA and protein synthesis mechanisms(6)

Publications31 total

Broadening the Scope of Binding Free Energy Calculations Using a Separated Topologies Approach
Journal of Chemical Theory and Computation·2023· 32 citedOpen Access
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells
Journal of the American Chemical Society·2023· 15 citedOpen Access
Broadening the scope of binding free energy calculations using a Separated Topologies approach
2023· 3 citedOpen Access
WITHDRAWN
2023Open Access
Cosolvent-Enhanced Sampling and Unbiased Identification of Cryptic Pockets Suitable for Structure-Based Drug Design
Journal of Chemical Theory and Computation·2019· 44 cited
Ensemble- and Rigidity Theory-Based Perturbation Approach To Analyze Dynamic Allostery
Journal of Chemical Theory and Computation·2017· 34 cited
A dynamic hydrophobic core orchestrates allostery in protein kinases
Science Advances·2017· 111 citedOpen Access
Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer
Proceedings of the National Academy of Sciences·2017· 60 citedOpen Access
Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases
PLoS Biology·2016· 54 citedOpen Access
Protein Dynamics Defines Allostery in the Conserved EPK Core
The FASEB Journal·2016
Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution
Journal of Medicinal Chemistry·2015· 52 citedOpen Access
A Computational Model for E. coli Cytoplasm: Diffusion and Hydrodynamics
Biophysical Journal·2015Open Access
Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling
Structure·2014· 64 citedOpen Access
Dynamic architecture of a protein kinase
Proceedings of the National Academy of Sciences·2014· 263 citedOpen Access
A New Coarse-Grained Model for E. coli Cytoplasm: Accurate Calculation of the Diffusion Coefficient of Proteins and Observation of Anomalous Diffusion
PLoS ONE·2014· 38 citedOpen Access
Dynamic architecture of a protein kinase (802.22)
The FASEB Journal·2014· 11 cited
The role of tyrosine sulfation in the dimerization of the CXCR4:SDF‐1 complex
Protein Science·2013· 13 citedOpen Access
Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
PLoS Computational Biology·2013· 11 citedOpen Access
Hydrogen Bond Strengths in Phosphorylated and Sulfated Amino Acid Residues
PLoS ONE·2013· 26 citedOpen Access
Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3
Journal of Biological Chemistry·2013· 52 citedOpen Access
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Frequent Co-authors

Matthew P. Jacobson(9), Susan S. Taylor(8), Alexandr P. Kornev(5), Gianluigi Veglia(5), David L. Mobley(4), Lalima G. Ahuja(4), James A. Wells(3), Hannah M. Baumann(3), Eric Dybeck(3), Frank C. Pickard(3), Vytautas Gapsys(3), Laura Pérez‐Benito(3), David F. Hahn(3), Gary Tresadern(3), Alan M. Mathiowetz(3), Gregory D. Friedland(2), Jonggul Kim(2), Alessandro Cembran(2), Larry R. Masterson(2), Markus Boehm(2)