Laura Pérez‐Benito

Johnson & Johnson (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index1.9kcitations59works14.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(30), Computational Drug Discovery Methods(20), Protein Structure and Dynamics(14), Chemical Synthesis and Analysis(12), Neuroscience and Neuropharmacology Research(9)

Publications59 total

Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli
Journal of Medicinal Chemistry·2025· 1 cited
Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity
Journal of Medicinal Chemistry·2025· 6 cited
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome
EMBO Molecular Medicine·2024· 6 citedOpen Access
Dataset for quantum-mechanical exploration of conformers and solvent effects in large drug-like molecules
Scientific Data·2024· 29 citedOpen Access
Aquamarine: Quantum-Mechanical Exploration of Conformers and Solvent Effects in Large Drug-like Molecules
2024· 1 citedOpen Access
Structural basis for the oligomerization-facilitated NLRP3 activation
Nature Communications·2024· 41 citedOpen Access
Alchemical Free Energy Calculations on Membrane-Associated Proteins
Journal of Chemical Theory and Computation·2023· 21 citedOpen Access
Broadening the Scope of Binding Free Energy Calculations Using a Separated Topologies Approach
Journal of Chemical Theory and Computation·2023· 32 citedOpen Access
Selective inhibitors of the PSEN1–gamma-secretase complex
Journal of Biological Chemistry·2023· 17 citedOpen Access
Broadening the scope of binding free energy calculations using a Separated Topologies approach
2023· 3 citedOpen Access
WITHDRAWN
2023Open Access
Reduction of stress responses in honey bees by synthetic ligands targeting an allatostatin receptor
Scientific Reports·2022· 5 citedOpen Access
Best Practices for Constructing, Preparing, and Evaluating Protein-Ligand Binding Affinity Benchmarks [Article v1.0]
Living Journal of Computational Molecular Science·2022· 73 citedOpen Access
Best practices for constructing, preparing, and evaluating protein-ligand binding affinity benchmarks
arXiv (Cornell University)·2021· 7 citedOpen Access
Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
Molecular Neurodegeneration·2020· 80 citedOpen Access
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB <sub>2</sub> Receptor**
Chemistry - A European Journal·2020· 24 citedOpen Access
Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome
Nature Methods·2020· 3 citedOpen Access
GPCRmd uncovers the dynamics of the 3D-GPCRome
Nature Methods·2020· 187 citedOpen Access
Discovery of Homobivalent Bitopic Ligands Of The Cannabinoid Cb2 Receptor
2020Open Access
Discovery of Homobivalent Bitopic Ligands Of The Cannabinoid Cb2 Receptor
2020Open Access
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Frequent Co-authors

Gary Tresadern(33), Arnau Cordomí(12), Andrés A. Trabanco(11), Leonardo Pardo(9), Herman van Vlijmen(8), David F. Hahn(6), Minos–Timotheos Matsoukas(5), Gianni De Fabritiis(5), Myriam Ciordia(5), Daniel Oehlrich(5), Hilde Lavreysen(5), Vytautas Gapsys(4), Pierre Matricon(4), Gemma Navarro(4), Rafael Franco(4), David L. Mobley(4), José M. Cid(4), Michiel Van Gool(4), Ismael Rodríguez‐Espigares(3), Mariona Torrens‐Fontanals(3)