Daniel Oehlrich

Johnson & Johnson (United States) — United States

Computer Science · Physical Sciences

25h-index1.9kcitations65works12.02yr avg
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Research Topics

Computational Drug Discovery Methods(12), Catalytic Cross-Coupling Reactions(11), Receptor Mechanisms and Signaling(10), Alzheimer's disease research and treatments(9), Chemical Synthesis and Analysis(9)

Publications65 total

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase
Journal of Virology·2025· 4 citedOpen Access
DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors
Journal of Medicinal Chemistry·2025· 3 cited
Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity
Journal of Medicinal Chemistry·2025· 6 cited
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome
EMBO Molecular Medicine·2024· 6 citedOpen Access
Structural basis for the oligomerization-facilitated NLRP3 activation
Nature Communications·2024· 41 citedOpen Access
Mutated Toll-like receptor 9 increases Alzheimer’s disease risk by compromising innate immunity protection
Molecular Psychiatry·2023· 15 citedOpen Access
Reductive site-selective atypical <i>C</i> , <i>Z</i> -type/N2-C2 cleavage allows C-terminal protein amidation
Science Advances·2022· 9 citedOpen Access
Publisher Correction: Post-translational insertion of boron in proteins to probe and modulate function
Nature Chemical Biology·2021Open Access
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo
ACS Medicinal Chemistry Letters·2021· 8 citedOpen Access
Reductive site-selective atypical C,Z-type / N2–C2 cleavage allows C-terminal protein amidation
2021Open Access
Reductive site-selective atypical C,Z-type / N2–C2 cleavage allows C-terminal protein amidation
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Post-translational insertion of boron in proteins to probe and modulate function
Nature Chemical Biology·2021· 34 citedOpen Access
Scaffold Hopping to Imidazo[1,2-<i>a</i>]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
ACS Omega·2021· 2 citedOpen Access
Post-translational insertion of boron in proteins to probe and modulate function
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Post-translational insertion of boron in proteins to probe and modulate function
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
CCDC 1973306: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
CCDC 1973307: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines
Journal of the American Chemical Society·2020· 72 citedOpen Access
3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 3 citedOpen Access
Hydrochlorofluoromethylation of unactivated alkenes with chlorofluoroacetic acid
Tetrahedron·2019· 9 citedOpen Access
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Frequent Co-authors

Andrés A. Trabanco(23), Frederik Rombouts(19), Gary Tresadern(18), Gregor J. Macdonald(15), Harrie J. M. Gijsen(11), Gary A. Molander(11), Juan A. Vega(10), Ana Isabel de Lucas(9), María Lourdes Linares(9), Marc Presset(8), José M. Cid(8), Encarnación Matesanz(8), Hilde Lavreysen(8), Michel Surkyn(8), Sven Van Brandt(7), Nicolas Fleury‐Brégeot(6), Michel De Cleyn(6), Virginie Colombel(6), Laura Pérez‐Benito(5), José Ignacio Andrés(5)