Tim J. Dalebout

Leiden University Medical Center — Netherlands

Medicine · Health Sciences

17h-index2.3kcitations30works0.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(17), Mosquito-borne diseases and control(7), Animal Virus Infections Studies(6), Viral Infections and Outbreaks Research(6), COVID-19 Clinical Research Studies(5)

Publications30 total

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase
Nature Communications·2023· 13 citedOpen Access
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19
Nature Immunology·2021· 125 citedOpen Access
A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses
Vaccines·2021· 7 citedOpen Access
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19
Zenodo (CERN European Organization for Nuclear Research)·2021· 2 citedOpen Access
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19
2021· 14 citedOpen Access
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP
The Journal of Experimental Medicine·2021· 69 citedOpen Access
Ad26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease
npj Vaccines·2021· 47 citedOpen Access
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Nature Communications·2021· 125 citedOpen Access
Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing
2021· 4 cited
Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques
2020· 10 citedOpen Access
Xrn1-resistant RNA structures are well-conserved within the genus flavivirus
RNA Biology·2020· 11 citedOpen Access
Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
npj Vaccines·2020· 368 citedOpen Access
Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
2020· 45 citedOpen Access
Capsid-like particles decorated with the SARS2-CoV-2 receptor-binding domain elicit strong virus neutralization activity
2020· 5 citedOpen Access
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
Journal of General Virology·2020· 627 citedOpen Access
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
2020· 70 citedOpen Access
The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model
2019· 8 citedOpen Access
The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease contributes to innate immune evasion and enhances viral virulence
2019
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
PLoS Pathogens·2017· 59 citedOpen Access
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses
PLoS Pathogens·2016· 193 citedOpen Access
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Frequent Co-authors

Marjolein Kikkert(21), Eric J. Snijder(14), Peter J. Bredenbeek(14), Sebenzile K. Myeni(12), Jutte J.C. de Vries(6), Joan E. M. van der Lubbe(6), Frank Wegmann(6), Dan H. Barouch(6), Roland Zahn(6), Hanneke Schuitemaker(6), Robert C. M. Knaap(6), Willy J. M. Spaan(6), Lucy Rutten(4), Adriaan H. de Wilde(4), Johannes P. M. Langedijk(4), Jerome Custers(4), Anna H.E. Roukens(4), M. Sesmu Arbous(4), Maria Yazdanbakhsh(4), Mirjam H.M. Heemskerk(4)