Adriaan H. de Wilde

Janssen (Netherlands) — Netherlands

Medicine · Health Sciences

16h-index3.4kcitations21works0.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(13), Animal Virus Infections Studies(13), Viral gastroenteritis research and epidemiology(11), Viral Infections and Immunology Research(6), Virus-based gene therapy research(3)

Publications21 total

Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP
The Journal of Experimental Medicine·2021· 69 citedOpen Access
Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques
2020· 10 citedOpen Access
Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
npj Vaccines·2020· 368 citedOpen Access
Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
2020· 45 citedOpen Access
A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis
PLoS Biology·2020· 466 citedOpen Access
A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis
2020· 100 citedOpen Access
Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors
Journal of Virology·2019· 6 citedOpen Access
Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits
2019Open Access
Cyclophilins and cyclophilin inhibitors in nidovirus replication
Virology·2018· 74 citedOpen Access
Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture
Virology·2017· 25 citedOpen Access
Host Factors in Coronavirus Replication
Current topics in microbiology and immunology·2017· 567 citedOpen Access
Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model
Virus Research·2016· 84 citedOpen Access
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins
Journal of Virology·2015· 75 citedOpen Access
Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity
Bioorganic & Medicinal Chemistry Letters·2015· 86 citedOpen Access
Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture
Antimicrobial Agents and Chemotherapy·2014· 746 citedOpen Access
CultureCoronavirus Replication in Cell Inhibitors of Middle East Respiratory Library Identifies Four Small-Molecule Screening of an FDA-Approved Compound
2014· 5 cited
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
Journal of General Virology·2013· 358 citedOpen Access
Cyclophilin Inhibitors Block Arterivirus Replication by Interfering with Viral RNA Synthesis
Journal of Virology·2012· 43 citedOpen Access
Cyclosporin A inhibits the replication of diverse coronaviruses
Journal of General Virology·2011· 246 citedOpen Access
The +RNA virus replication and transcription complex: hijacking membranes to accommodate viral RNA synthesis in the cytoplasm
2008· 1 cited
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Frequent Co-authors

Eric J. Snijder(21), Clara C. Posthuma(9), Marjolein Kikkert(7), Jessika C. Zevenhoven-Dobbe(6), Martijn J. van Hemert(6), Montserrat Bárcena(6), Anja W. M. de Jong(4), Joan E. M. van der Lubbe(4), Frank Wegmann(4), Tim J. Dalebout(4), Sebenzile K. Myeni(4), Dan H. Barouch(4), Roland Zahn(4), Jerome Custers(4), Hanneke Schuitemaker(4), Dirk Jochmans(3), Stefan van Nieuwkoop(3), Theo M. Bestebroer(3), Bernadette G. van den Hoogen(3), Ronald W.A.L. Limpens(3)