Luke L. Lairson

Scripps Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index7.5kcitations111works24.12yr avg
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Research Topics

Glycosylation and Glycoproteins Research(16), Carbohydrate Chemistry and Synthesis(12), interferon and immune responses(10), Pluripotent Stem Cells Research(9), X-ray Diffraction in Crystallography(8)

Publications111 total

Microbiota-derived secondary bile acids promote STING activation and antitumor activity
2025· 3 citedOpen Access
Distinct oligomeric assemblies of STING induced by non-nucleotide agonists
Nature Communications·2025· 3 citedOpen Access
Insights into Free Drug Release from Efficacious <i>N</i>-Acyl <i>O</i>-Aminophenol Duocarmycin Prodrugs
ACS Chemical Biology·2025Open Access
Induced cell phenotype activity recording of DNA-tagged ligands
RSC Chemical Biology·2024Open Access
Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase
Bioorganic & Medicinal Chemistry Letters·2024· 1 cited
TERT activation targets DNA methylation and multiple aging hallmarks
Cell·2024· 73 citedOpen Access
JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma
Science·2024· 131 citedOpen Access
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins
Biochemistry·2024· 5 cited
Discovery of PLD4 modulators by high-throughput screening and kinetic analysis
Results in Chemistry·2024· 1 citedOpen Access
Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
Cell Reports·2023· 16 citedOpen Access
A new road to STING activation
Nature Chemical Biology·2023· 2 cited
Author Correction: Synthesis of portimines reveals the basis of their anti-cancer activity
Nature·2023· 2 citedOpen Access
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization
Cell Reports Methods·2023· 17 citedOpen Access
Synthesis of portimines reveals the basis of their anti-cancer activity
Nature·2023· 57 citedOpen Access
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
Cell chemical biology·2023· 6 citedOpen Access
Combination-Based Drug Screening for Induced Oligodendrocyte Differentiation Enables Mechanistic Insight and Identifies Optimal Drug Pairs for Remyelination
2023Open Access
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A
Nature Chemical Biology·2023· 34 cited
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators
Bioorganic & Medicinal Chemistry Letters·2023· 3 citedOpen Access
A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death
Journal of the American Chemical Society·2023· 10 citedOpen Access
A Scalable Total Synthesis of Portimine A and B Reveals the Basis of Their Potent and Selective Anti-cancer Activity
2023· 2 citedOpen Access
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Frequent Co-authors

Peter G. Schultz(15), Costas A. Lyssiotis(11), Stephen G. Withers(9), Michael J. Bollong(8), Warren W. Wakarchuk(8), Emily N. Chin(7), Reza Beheshti Zavareh(7), Francisco Martínez‐Peña(6), N.C.J. Strynadka(6), Shoutian Zhu(6), Justin L. Anglin(5), Heiko Wurdak(5), Brittney A. Beyer(5), John R. Teijaro(4), Edouard Mullarky(4), Lewis C. Cantley(4), Cecilia Chiu(4), Gary Siuzdak(4), Insha Ahmad(3), Philipp N. Sander(3)