Renée Vancraenenbroeck

Institute of Structural and Molecular Biology — United Kingdom

Medicine · Health Sciences

16h-index1.2kcitations39works0.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(10), Fungal and yeast genetics research(6), Plant Gene Expression Analysis(6), Protein Structure and Dynamics(4), Protein Kinase Regulation and GTPase Signaling(4)

Publications39 total

Model-free photon analysis of diffusion-based single-molecule FRET experiments
Nature Communications·2025Open Access
Electrostatics and hydrophobicity in the dynamics of intrinsically disordered proteins
The European Physical Journal E·2023· 4 citedOpen Access
Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor
Proceedings of the National Academy of Sciences·2021· 18 citedOpen Access
Quantification and demonstration of the constriction-by-rachet mechanism in the dynamin molecular motor
2020Open Access
Polymer effects modulate binding affinities in disordered proteins
Proceedings of the National Academy of Sciences·2019· 86 citedOpen Access
Artificial GTPase-BSE dimer of human Dynamin1
2019
Occupancies in the DNA-Binding Pathways of Intrinsically Disordered Helix-Loop-Helix Leucine-Zipper Proteins
The Journal of Physical Chemistry B·2018· 19 cited
Faculty Opinions recommendation of Controllable protein phase separation and modular recruitment to form responsive membraneless organelles.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
Scientific Reports·2017· 54 citedOpen Access
Development of a range of fluorescent reagentless biosensors for ATP, based on malonyl-coenzyme A synthetase
PLoS ONE·2017· 3 citedOpen Access
A Fluorescent, Reagentless Biosensor for ATP, Based on Malonyl-Coenzyme A Synthetase
ACS Chemical Biology·2015· 15 citedOpen Access
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
Frontiers in Molecular Neuroscience·2014· 57 citedOpen Access
Dissection of the molecular mechanism of action of LRRK2 kinase inhibitors, a potential disease modifying treatment for PD
Lirias (KU Leuven)·2013
Combined in silico, in vitro and in cellulo analysis of ATP binding site kinase inhibitors shows a direct correlation between potency to inhibit LRRK2 kinase activity in vitro and potency to dephosphorylate LRRK2 at Ser935 in mammalian cell
2013
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
Human Molecular Genetics·2012· 247 citedOpen Access
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
PLoS ONE·2012· 102 citedOpen Access
Evidence for DNA-Binding Domain–Ligand-Binding Domain Communications in the Androgen Receptor
Molecular and Cellular Biology·2012· 60 citedOpen Access
Electron microscopy analysis of purified LRRK1 and LRRK2 demonstrates formation of dimers
2012
Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2012· 26 cited
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Frequent Co-authors

Veerle Baekelandt(21), Jean‐Marc Taymans(21), Marc De Maeyer(19), Evy Lobbestael(17), Fangye Gao(9), Hagen Hofmann(9), Elisa Greggio(7), Mark Cookson(7), Veronique Daniëls(6), Alexandra Beilina(5), Gabriel Rosenblum(4), Laura Civiero(3), Lauran Reyniers(3), Luigi Bubacco(3), Arnout Voet(3), Oleg Ganichkin(3), Oliver Daumke(3), Jeffrey K. Noel(3), Petri Ollikainen(2), Elisa Belluzzi(2)