Niles A. Pierce

California Institute of Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index15.7kcitations88works5.32yr avg
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Research Topics

Advanced biosensing and bioanalysis techniques(52), DNA and Nucleic Acid Chemistry(23), RNA and protein synthesis mechanisms(20), RNA Interference and Gene Delivery(18), Computational Fluid Dynamics and Aerodynamics(15)

Publications87 total

Models and Algorithms for Equilibrium Analysis of Mixed-Material Nucleic Acid Systems
ACS Synthetic Biology·2026
<i>k</i> -spaces: Mixtures of Gaussian latent variable models
2025Open Access
NUPACK: Analysis and Design of Nucleic Acid Structures, Devices, and Systems
2025· 2 cited
Models and Algorithms for Equilibrium Analysis of Mixed-Material Nucleic Acid Systems
2025Open Access
HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples
Development·2024· 19 citedOpen Access
Multiplex, Quantitative, High-Resolution Imaging of Protein:Protein Complexes via Hybridization Chain Reaction
ACS Chemical Biology·2024· 11 citedOpen Access
HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples
2023· 6 citedOpen Access
Multiplex, quantitative, high-resolution imaging of protein:protein complexes via hybridization chain reaction
2023· 1 citedOpen Access
Hybridization Chain Reaction Lateral Flow Assays for Amplified Instrument-Free At-Home SARS-CoV-2 Testing
ACS Infectious Diseases·2023· 18 citedOpen Access
NUPACK: Analysis and Design of Nucleic Acid Structures, Devices, and Systems
2022· 72 citedOpen Access
HCR Lateral Flow Assays for Amplified Instrument-Free At-Home SARS-CoV-2 Testing
2022Open Access
Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel
Life Sciences in Space Research·2022· 15 citedOpen Access
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and <i>in situ</i> hybridization
Development·2021· 102 citedOpen Access
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization
2021· 20 citedOpen Access
High-Performance Allosteric Conditional Guide RNAs for Mammalian Cell-Selective Regulation of CRISPR/Cas
ACS Synthetic Biology·2021· 36 cited
A Unified Dynamic Programming Framework for the Analysis of Interacting Nucleic Acid Strands: Enhanced Models, Scalability, and Speed
ACS Synthetic Biology·2020· 97 cited
Multiplexed Quantitative In Situ Hybridization for Mammalian Cells on a Slide: qHCR and dHCR Imaging (v3.0)
Methods in molecular biology·2020· 4 cited
Multiplexed Quantitative In Situ Hybridization with Subcellular or Single-Molecule Resolution Within Whole-Mount Vertebrate Embryos: qHCR and dHCR Imaging (v3.0)
Methods in molecular biology·2020· 22 cited
Multiplexed Quantitative In Situ Hybridization for Mammalian or Bacterial Cells in Suspension: qHCR Flow Cytometry (v3.0)
Methods in molecular biology·2020· 2 cited
Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacterial and Mammalian Cells via Dynamic RNA Nanotechnology
ACS Central Science·2019· 111 citedOpen Access
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Frequent Co-authors

Harry M. T. Choi(14), Michael B. Giles(11), Robert M. Dirks(8), Maayan Schwarzkopf(8), Mark E. Fornace(5), Brian R. Wolfe(4), Scott E. Fraser(4), Joseph N. Zadeh(3), Peng Yin(3), Colby R. Calvert(3), Erik Winfree(3), N. Husain(3), Nicholas J. Porubsky(3), Lisa M. Hochrein(3), Samuel J. Schulte(3), Justin S. Bois(2), Marshall B. Pierce(2), Aneesh Acharya(2), Georgios Artavanis(2), Johannes Stegmaier(2)