Sarah L. Gaffen

University of Pittsburgh — United States

Immunology and Microbiology · Life Sciences

75h-index23.9kcitations325works7.52yr avg
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Research Topics

Psoriasis: Treatment and Pathogenesis(98), Antifungal resistance and susceptibility(82), Immunodeficiency and Autoimmune Disorders(66), Cytokine Signaling Pathways and Interactions(55), Fungal Infections and Studies(40)

Publications325 total

The RNA binding protein Arid5a is an activator of TNF signaling in rheumatoid arthritis
JCI Insight·2026Open Access
Epitranscriptomic control of host epithelial responses to candidiasis via N6-Methyladenosine (m <sup>6</sup> A) methylation
2025Open Access
An estrogen-independent and IL-1-dependent pathway controls vulvovaginal candidiasis through combined IL-17/IL-22 signaling
2025Open Access
Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral <i>Candida albicans</i> exposure
mBio·2025Open Access
Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance
2024· 3 citedOpen Access
Focus on fungi
Cell·2024· 49 citedOpen Access
Therapeutic delivery of CCL2 modulates immune response and restores host–microbe homeostasis
Proceedings of the National Academy of Sciences·2024· 7 citedOpen Access
An IL-17-DUOX2 axis controls gastrointestinal colonization by <i>Candida albicans</i>
2024· 2 citedOpen Access
C/EBPδ Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner
The Journal of Immunology·2024· 3 citedOpen Access
The RNA binding protein Arid5a drives IL-17–dependent autoantibody-induced glomerulonephritis
The Journal of Experimental Medicine·2024· 9 citedOpen Access
Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs
PLoS Pathogens·2024· 10 citedOpen Access
Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint
Science Signaling·2023· 5 citedOpen Access
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis
Cell Host & Microbe·2023· 16 citedOpen Access
SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor
The Journal of Immunology·2023· 13 citedOpen Access
When IL-17 gets on your nerves
Cell·2023· 9 citedOpen Access
A gut-oral microbiome–driven axis controls oropharyngeal candidiasis through retinoic acid
JCI Insight·2022· 19 citedOpen Access
Arid5a Mediates an IL-17–Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense
The Journal of Immunology·2022· 9 citedOpen Access
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
Journal of Biological Chemistry·2022· 20 citedOpen Access
Th17-driven immunity to oral candidiasis is dependent on the microbiome and can be triggered by mono-colonization with segmented filamentous bacteria.
The Journal of Immunology·2022· 1 cited
Faculty Opinions recommendation of Risk of candidiasis associated with interleukin-17 inhibitors: A real-world observational study of multiple independent sources.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2022
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Frequent Co-authors

Fang Shen(8), Heather R. Conti(7), Abhishek V. Garg(6), Mandy J. McGeachy(5), Jay K. Kolls(5), Julian R. Naglik(5), Shabaana A. Khader(4), Matthew J. Ruddy(4), Nydiaris Hernández‐Santos(4), Anna R. Huppler(4), Bernhard Hube(4), Jeffrey Yu(3), Xikui K. Liu(3), Jonathan P. Richardson(3), J. Daniel(2), Javier Rangel‐Moreno(2), Troy D. Randall(2), Scott G. Filler(2), Mira Edgerton(2), Reiko Onishi(2)