Bon Ham Yip

Medicine · Health Sciences

17h-index1.4kcitations32works4.02yr avg
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Research Topics

Acute Myeloid Leukemia Research(20), RNA Research and Splicing(9), RNA modifications and cancer(6), Myeloproliferative Neoplasms: Diagnosis and Treatment(4), CRISPR and Genetic Engineering(3)

Publications32 total

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
Nature Genetics·2025· 4 citedOpen Access
Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A
Blood·2023· 3 citedOpen Access
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
Nature Communications·2023· 11 citedOpen Access
3031 – CHROMOTHRIPSIS AND LEUKEMIC TRANSFORMATION IN MPN
Experimental Hematology·2023
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
2022· 1 citedOpen Access
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3
Journal of Clinical Investigation·2021· 83 citedOpen Access
Recent Advances in CRISPR/Cas9 Delivery Strategies
Biomolecules·2020· 292 citedOpen Access
Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media
Molecular Therapy — Methods & Clinical Development·2019· 95 citedOpen Access
PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia
Leukemia·2018· 16 citedOpen Access
L-leucine increases translation of <i>RPS14</i> and <i>LARP1</i> in erythroblasts from del(5q) myelodysplastic syndrome patients
Haematologica·2018· 9 citedOpen Access
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
Journal of Clinical Investigation·2017· 18 citedOpen Access
Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia
Haematologica·2017· 2 citedOpen Access
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
Journal of Clinical Investigation·2017· 96 citedOpen Access
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
Leukemia·2016· 135 citedOpen Access
Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes
Current Pharmaceutical Design·2016· 18 cited
Lineage-Specific Aberrant mRNA Splicing By U2AF1 Mutation Alters Erythroid and Granulomonocytic Differentiation
Blood·2015· 3 cited
<i>ASXL1</i> mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts
Oncotarget·2015· 72 citedOpen Access
Application of genome editing technologies to the study and treatment of hematological disease
Advances in Biological Regulation·2015· 18 cited
Erratum: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
Leukemia·2015· 47 citedOpen Access
Corrigendum: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (vol 29, pg 1092, 2015)
Lirias (KU Leuven)·2015
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Frequent Co-authors

Andrea Pellagatti(21), Jacqueline Boultwood(21), Hamid Dolatshad(12), Marta Fernández‐Mercado(8), Elli Papaemmanuil(7), John D. Crispino(6), James S. Wainscoat(6), Luca Malcovati(5), Martin Attwood(5), Laura Scifo(5), Jacqueline Shaw(5), Sally Killick(5), Swagata Roy(5), Natasha Sahgal(4), Alexander Kanapin(4), Helen Lockstone(4), Peter Vandenberghe(4), Christopher W. J. Smith(4), Jaroslaw P. Maciejewski(4), Mario Cazzola(4)