Natalia Chernyak

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Immunology and Microbiology · Life Sciences

7h-index713citations17works3.52yr avg
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Research Topics

Immunotherapy and Immune Responses(12), RNA Interference and Gene Delivery(9), Immune Response and Inflammation(7), Cancer Immunotherapy and Biomarkers(3), Immune Cell Function and Interaction(2)

Publications17 total

<i>N</i> -Alkyl and <i>N</i> -Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors
ACS Medicinal Chemistry Letters·2026
Transition Metal-Catalyzed Synthesis and Functionalization of Carbo- and Heterocycles.
Figshare·2025Open Access
Discovery and Evaluation of TLR-Targeted Immune Agonists
Journal of Medicinal Chemistry·2024· 5 cited
Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads
Journal of Medicinal Chemistry·2024· 9 cited
Development and application of an in vitro assay to assess target-independent B-cell activation by targeted TLR7 immune agonists
Journal of Immunological Methods·2023· 2 cited
Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions
Bioconjugate Chemistry·2023· 9 cited
Development and Application of an in Vitro Assay to Assess Target-Independent B-Cell Activation by Targeted Tlr7/8 Immune Agonists
SSRN Electronic Journal·2023Open Access
Immunomodulatory Spherical Nucleic Acids*
Spherical Nucleic Acids·2020
Immunomodulatory Spherical Nucleic Acids*
Spherical Nucleic Acids·2020
Immunomodulatory Spherical Nucleic Acids*
Spherical Nucleic Acids·2020
RNA‐Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators
Small·2019· 11 citedOpen Access
Robust antitumor effects of SNA-based T cell therapy
The Journal of Immunology·2019
RNA‐Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators
Small·2018· 68 citedOpen Access
Novel T cell therapy using spherical nucleic acids
The Journal of Immunology·2018
Tip-Directed Synthesis of Multimetallic Nanoparticles
Journal of the American Chemical Society·2015· 157 cited
Immunomodulatory spherical nucleic acids
Proceedings of the National Academy of Sciences·2015· 247 citedOpen Access
Liposomal Spherical Nucleic Acids
Journal of the American Chemical Society·2014· 205 citedOpen Access

Frequent Co-authors

Chad A. Mirkin(8), Aleksandar F. Radovic‐Moreno(4), Christopher C. Mader(4), SubbaRao Nallagatla(4), Richard S. Kang(4), Liangliang Hao(4), David Walker(4), Tiffany L. Halo(4), Timothy J. Merkel(4), Clayton H. Rische(4), Sagar Anantatmula(4), Merideth Burkhart(4), Sergei Gryaznov(4), Donye Dominguez(4), Aarron Willingham(4), Esther Kofman(4), Jin‐Hwan Han(4), Bhagyashree Bhagwat(4), W. Michael Seganish(4), Bin Zhang(3)