Diane M. Papazian

University of California, Los Angeles — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index7.4kcitations84works0.02yr avg
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Research Topics

Ion channel regulation and function(61), Cardiac electrophysiology and arrhythmias(27), Neuroscience and Neuropharmacology Research(23), Genetic Neurodegenerative Diseases(16), Neurobiology and Insect Physiology Research(11)

Publications84 total

Altered closed state inactivation gating in Kv4.2 channels results in developmental and epileptic encephalopathies in human patients
Human Mutation·2022· 5 cited
Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo
eLife·2020· 16 citedOpen Access
Author response: Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo
2020Open Access
Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening
Proceedings of the National Academy of Sciences·2018· 45 citedOpen Access
Extracellular Loose-Patch Recording of Purkinje Cell Activity in Awake Zebrafish and Emergence of Functional Cerebellar Circuit
Neuromethods·2017· 3 cited
In Vivo Analysis of Potassium Channelopathies: Loose Patch Recording of Purkinje Cell Firing in Living, Awake Zebrafish
Methods in molecular biology·2017· 3 cited
Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner
Cellular and Molecular Life Sciences·2015· 31 citedOpen Access
Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish
Frontiers in Neural Circuits·2014· 40 citedOpen Access
Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation
Human Molecular Genetics·2014· 121 citedOpen Access
Kcnd2 Mutation Associated with Autism and Epilepsy Impairs Inactivation Gating in Kv4.2 K+ Channels
Biophysical Journal·2014· 2 citedOpen Access
Altered Kv3.3 channel gating in early‐onset spinocerebellar ataxia type 13
The Journal of Physiology·2012· 45 citedOpen Access
Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development
Disease Models & Mechanisms·2012· 27 citedOpen Access
R1 in the Shaker S4 occupies the gating charge transfer center in the resting state
The Journal of General Physiology·2011· 51 citedOpen Access
Spinocerebellar Ataxia Type 13 Mutant Potassium Channel Alters Neuronal Excitability and Causes Locomotor Deficits in Zebrafish
Journal of Neuroscience·2011· 51 citedOpen Access
Frequency of KCNC3 DNA Variants as Causes of Spinocerebellar Ataxia 13 (SCA13)
PLoS ONE·2011· 52 citedOpen Access
Neural circuit activity in freely behaving zebrafish (<i>Danio rerio</i>)
Journal of Experimental Biology·2011· 58 citedOpen Access
R1 in the Shaker S4 Occupies the Gating Charge Transfer Center in the Resting State
Biophysical Journal·2011· 20 citedOpen Access
Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels
BMC Neuroscience·2010· 25 citedOpen Access
Transfer of ion binding site from ether-à-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening
The Journal of General Physiology·2010· 9 citedOpen Access
Experimental Constraints for the Resting Structure of the Shaker Voltage Sensor Domain Derived from Engineered High and Low Affinity Zn2+ Binding Sites
Biophysical Journal·2010Open Access
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Frequent Co-authors

Allan F. Mock(11), Lily Yeh Jan(9), Meng‐Chin Lin(8), Yuh Nung Jan(7), Francisco Bezanilla(7), Thomas L. Schwarz(6), Bruce L. Tempel(5), Christine T. Schulteis(5), Leslie C. Timpe(4), Natali A. Minassian(4), John P. Bannister(4), William R. Silverman(4), Chih‐Yung Tang(4), Fadi A. Issa(4), Jui-Yi Hsieh(4), Yü Huang(3), Karla P. Figueroa(3), Stefan M. Pulst(3), Eduardo Perozo(3), Enrico Stefani(3)