Lothar Lindemann

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.9kcitations55works1.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(17), Neuroscience and Neuropharmacology Research(15), Genetics and Neurodevelopmental Disorders(14), Autism Spectrum Disorder Research(8), Tryptophan and brain disorders(6)

Publications55 total

Development and Characterization of a Novel α-Synuclein-PEST H4 Cell Line for Enhanced Drug Screening in α-Synucleinopathies
International Journal of Molecular Sciences·2025Open Access
Orally Bioavailable Dopamine D1/D5 Receptor-Biased Agonists to Study the Role of β-Arrestin in Treatment-Related Dyskinesia in Parkinson’s Disease
Journal of Medicinal Chemistry·2025· 1 cited
Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
Alzheimer s Research & Therapy·2025Open Access
γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds
Alzheimer s Research & Therapy·2025· 4 citedOpen Access
Gamma‐secretase modulation: from bench to clinic
Alzheimer s & Dementia·2024Open Access
Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors
Neuropharmacology·2020· 24 citedOpen Access
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
University of Southern Denmark Research Portal (University of Southern Denmark)·2018Open Access
3.2 PARVALBUMIN INTERNEURON IMPAIRMENT INDUCED BY OXIDATIVE STRESS AS A COMMON PATHOLOGICAL MECHANISM IN ANIMAL MODELS OF SCHIZOPHRENIA
Schizophrenia Bulletin·2018· 1 citedOpen Access
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
Nature Reviews Drug Discovery·2017· 339 citedOpen Access
mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex
Neuropsychopharmacology·2017· 43 citedOpen Access
Results and evaluation of a first‐in‐human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods
British Journal of Clinical Pharmacology·2017· 13 citedOpen Access
Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results
Neuropsychopharmacology·2017· 125 citedOpen Access
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Molecular Psychiatry·2017· 350 citedOpen Access
Drug Discovery for Targeted Pharmacotherapy of Fragile X Syndrome
Elsevier eBooks·2017· 3 cited
Contributors
Elsevier eBooks·2017
Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences
Brain Behavior and Immunity·2016· 18 cited
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex
Proceedings of the National Academy of Sciences·2015· 29 citedOpen Access
Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Journal of Pharmacology and Experimental Therapeutics·2015· 102 cited
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion
Nature Neuroscience·2015· 109 citedOpen Access
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1<i>H</i>-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases
Journal of Medicinal Chemistry·2015· 63 citedOpen Access
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Frequent Co-authors

Georg Jaeschke(13), Joseph G. Wettstein(12), Marius C. Hoener(12), Will Spooren(10), Mark F. Bear(7), Eric Prinssen(7), Aubin Michalon(6), Richard H. Porter(6), Laurence Ozmen(5), Michael Honer(5), Edilio Borroni(4), Sebastian H. Scharf(4), Martin Ebeling(4), Nicole A. Kratochwil(4), Sabine Kolczewski(4), Tomi Rantamäki(4), Eero Ċastrén(4), Michael S. Sidorov(3), Theresa M. Ballard(3), Bernhard Bettler(3)