Eric Prinssen

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index3.8kcitations71works0.52yr avg
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Research Topics

Receptor Mechanisms and Signaling(32), Neuroscience and Neuropharmacology Research(20), Neurotransmitter Receptor Influence on Behavior(16), Influenza Virus Research Studies(11), Neuropeptides and Animal Physiology(11)

Publications71 total

Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders
2025Open Access
Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling
Frontiers in Pharmacology·2025· 1 citedOpen Access
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation
iScience·2023· 4 citedOpen Access
Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Scientific Reports·2021· 36 citedOpen Access
Preclinical and Clinical Pharmacology of Basmisanil, a Novel Selective GABAA-α5 Receptor Negative Allosteric Modulator
2020· 1 citedOpen Access
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds
UNC Libraries·2020Open Access
Mapping the impact of exposure to maternal immune activation on juvenile Wistar rat brain macro- and microstructure during early post-natal development
Brain and Neuroscience Advances·2019· 5 citedOpen Access
Preliminary evidence that maternal immune activation specifically increases diagonal domain volume in the rat brain during early postnatal development
2018Open Access
Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects
Brain Behavior and Immunity·2018· 88 citedOpen Access
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease
Journal of Pharmacology and Experimental Therapeutics·2017· 84 citedOpen Access
The great barrier belief: The blood–brain barrier and considerations for juvenile toxicity studies
Reproductive Toxicology·2017· 44 cited
Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets
Nature Reviews Drug Discovery·2016· 78 citedOpen Access
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds
Nature Chemical Biology·2016· 156 citedOpen Access
“Domain gauges”: A reference system for multivariate profiling of brain fMRI activation patterns induced by psychoactive drugs in rats
NeuroImage·2015· 21 cited
Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Journal of Pharmacology and Experimental Therapeutics·2015· 102 cited
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1<i>H</i>-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases
Journal of Medicinal Chemistry·2015· 63 citedOpen Access
Can 5-HT3 antagonists contribute toward the treatment of schizophrenia?
Behavioural Pharmacology·2014· 29 cited
Maternal immune activation and abnormal brain development across CNS disorders
Nature Reviews Neurology·2014· 876 cited
Poster #M239 EXPLORATION OF THE THERAPEUTIC POTENTIAL OF SELECTIVE TAAR1 AGONISTS IN PRECLINICAL PARADIGMS
Schizophrenia Research·2014
Post-Marketing Assessment of Neuropsychiatric Adverse Events in Influenza Patients Treated with Oseltamivir: An Updated Review
Advances in Therapy·2012· 45 citedOpen Access
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Frequent Co-authors

Will Spooren(9), Sabine Kolczewski(9), Richard H. Porter(8), Georg Jaeschke(7), Jürgen Wichmann(7), Eric Vieira(7), Joseph G. Wettstein(7), Wouter Koek(7), Bart Ellenbroek(7), Theresa M. Ballard(6), Mark S. Kleven(6), Jens‐Uwe Peters(5), Laurent B. Nicolas(5), Gerhard Hoffmann(5), Lothar Lindemann(5), Alexander R. Cools(5), Bernd Büttelmann(4), Craig R. Rayner(4), Tom Chu(4), Edilio Borroni(4)