Dmitriy Lukashev

Novartis (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index5.6kcitations37works0.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(21), Immune Cell Function and Interaction(15), Cancer, Hypoxia, and Metabolism(8), RNA and protein synthesis mechanisms(4), RNA Research and Splicing(4)

Publications37 total

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion
Nature Communications·2022· 116 citedOpen Access
Author Correction: Regulated control of gene therapies by drug-induced splicing
Nature·2022Open Access
Regulated control of gene therapies by drug-induced splicing
Nature·2021· 131 citedOpen Access
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
Journal of Clinical Investigation·2017· 3 citedOpen Access
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Science Translational Medicine·2015· 579 cited
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
Journal of Molecular Medicine·2014· 195 citedOpen Access
Hostile, Hypoxia–A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists
Cancer Immunology Research·2014· 207 citedOpen Access
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
Journal of Clinical Investigation·2014Open Access
Novel RNA interference-based therapies for sepsis
Expert Opinion on Biological Therapy·2014· 5 cited
Genetic deletion of the <scp>HIF</scp>‐1α isoform I.1 in <scp>T</scp> cells enhances antibacterial immunity and improves survival in a murine peritonitis model
European Journal of Immunology·2012· 17 citedOpen Access
In Vivo Hypoxic Preconditioning Protects From Warm Liver Ischemia-Reperfusion Injury Through the Adenosine A2B Receptor
Transplantation·2012· 48 cited
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
Journal of Clinical Investigation·2012· 106 citedOpen Access
A2B Adenosine Receptor Blockade Enhances Macrophage-Mediated Bacterial Phagocytosis and Improves Polymicrobial Sepsis Survival in Mice
The Journal of Immunology·2011· 94 citedOpen Access
Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α
Neoplasia·2010· 93 citedOpen Access
The antihypoxia–adenosinergic pathogenesis as a result of collateral damage by overactive immune cells
Journal of Leukocyte Biology·2009· 16 cited
Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia
Clinical Cancer Research·2008· 250 citedOpen Access
Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1α in activated human T lymphocytes
Human Immunology·2008· 24 citedOpen Access
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells
British Journal of Pharmacology·2008· 124 citedOpen Access
Critical Role of Hypoxia and A2A Adenosine Receptors in Liver Tissue-Protecting Physiological Anti-Inflammatory Pathway
Molecular Medicine·2008· 59 citedOpen Access
1,3,7-Trimethylxanthine (Caffeine) May Exacerbate Acute Inflammatory Liver Injury by Weakening the Physiological Immunosuppressive Mechanism
The Journal of Immunology·2007· 82 citedOpen Access
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Frequent Co-authors

Michail V. Sitkovsky(30), Akio Ohta(17), Sergey Apasov(7), Stephen Hatfield(6), Bryan Belikoff(6), Edwin K. Jackson(5), Charles C. Caldwell(5), Hidefumi Kojima(3), Manfred Thiel(3), Jørgen Kjaergäard(3), Robert Abbott(3), Alex Mas Monteys(3), Rajeev Sivasankaran(3), Beverly L. Davidson(3), Almut Grenz(3), Jessica D. Bauerle(3), Julee H. Dalton(3), Douglas Ridyard(3), Alexander Badulak(3), Eunyoung Tak(3)