David C. Fry

Birmingham and Solihull Mental Health NHS Foundation Trust — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.8kcitations76works5.32yr avg
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Research Topics

Chemical Synthesis and Analysis(20), Protein Structure and Dynamics(14), Computational Drug Discovery Methods(10), Ubiquitin and proteasome pathways(10), Enzyme Structure and Function(10)

Publications76 total

MGH2Home: Integrating Interdisciplinary Care for Seamless Transitions from Hospital to Home
International Journal of Integrated Care·2025Open Access
Key themes and approaches in palliative and end-of-life care education for the general public: a systematic review
BMC Palliative Care·2025· 4 citedOpen Access
The MGH2Home Program, a Seamless Journey from Hospital to Home
International Journal of Integrated Care·2025Open Access
Mechanistic Role of Biotin in Enzymatic Carboxylation Reactions
2024· 1 cited
Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development
ACS Medicinal Chemistry Letters·2024· 26 citedOpen Access
Implementation and Impact of a Lifting Cushion for Care Home Residents Who Have Fallen
International Journal of Older People Nursing·2024· 1 citedOpen Access
Records and Reports
2018
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease
Human Molecular Genetics·2016· 180 citedOpen Access
Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease
Human Molecular Genetics·2016· 174 citedOpen Access
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies
Journal of Biological Chemistry·2016· 21 citedOpen Access
X-RAY STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN
2016
Garrison Institute on Aging: A New Hope for Elderly Individuals and Patients with Alzheimer’s Disease
Journal of Alzheimer s Disease·2015· 3 citedOpen Access
Targeting Protein-Protein Interactions for Drug Discovery
Methods in molecular biology·2015· 42 cited
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction
ACS Medicinal Chemistry Letters·2014· 166 citedOpen Access
Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor
ACS Medicinal Chemistry Letters·2013· 57 citedOpen Access
Design of Libraries Targeting Protein–Protein Interfaces
ChemMedChem·2013· 35 cited
Modulators of Protein–Protein Interactions: Importance of Three‐Dimensionality
Methods and principles in medicinal chemistry·2013· 4 cited
Small-Molecule Inhibitors of Protein-Protein Interactions: How to Mimic a Protein Partner
Current Pharmaceutical Design·2012· 45 cited
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Proceedings of the National Academy of Sciences·2012· 223 citedOpen Access
Druggability Assessment of Protein–Protein Interfaces
Future Medicinal Chemistry·2011· 45 cited
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Frequent Co-authors

Albert S. Mildvan(12), Vincent Madison(9), Jefferson Tilley(6), S. Donald Emerson(6), Waleed Danho(6), David N. Greeley(6), Bradford Graves(5), Robert M. Campbell(5), Stephen A. Kuby(4), Charles M. Cook(4), V. Toome(4), Binh Thanh Vu(4), E. T. Kaiser(4), Paola Di Lello(3), Kuo‐Sen Huang(3), A. Felix(3), B. Wegrzynski(3), Richard Trilles(3), Robert E. Palermo(3), Joseph Swistok(3)