Jefferson Tilley

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.2kcitations251works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(29), Various Chemistry Research Topics(19), Peptidase Inhibition and Analysis(19), Cell Adhesion Molecules Research(18), Carbohydrate Chemistry and Synthesis(14)

Publications251 total

Abstract 2643: Design and discovery of novel oral INV-88 macrophage migration inhibitory factor (MIF) inhibitors: Potent anti-tumor activity <i>in vitro</i> and <i>in vivo</i>
Cancer Research·2022
Faculty Opinions recommendation of Amide bond bioisosteres: strategies, synthesis, and successes.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of Molecular Interactions of Pyrazine-based Compounds to Proteins.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of Metabolism and bioactivation: it's time to expect the unexpected.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2020
Faculty Opinions recommendation of Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019· 1 cited
Faculty Opinions recommendation of Logd contributions of substituents commonly used in medicinal chemistry.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Water networks can determine the affinity of ligand binding to proteins.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Designing around Structural Alerts in Drug Discovery.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, &lt;i&gt;N&lt;/i&gt; , &lt;i&gt;N&lt;/i&gt; -Dimethylformamide, and &lt;i&gt;N&lt;/i&gt; , &lt;i&gt;N&lt;/i&gt; -Dimethylacetamide.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
N-[ω-(Heteroaryl)Alkyl]Carboxamide Derivatives as Platelet Activating Factor Antagonists: Structure-Activity Relationships and Biological Data
2019
Faculty Opinions recommendation of Discovery of irreversible inhibitors targeting histone methyltransferase, SMYD3.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Construction of Natural-Product-Like Cyclophane-Braced Peptide Macrocycles via sp3 C-H Arylation.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2019
Faculty Opinions recommendation of Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
Faculty Opinions recommendation of Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2018
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Frequent Co-authors

Virginia Schwinge(8), Waleed Danho(7), Rolf Wagner(7), Robert Guthrie(6), Ramakanth Sarabu(6), David C. Fry(5), Richard Trilles(5), Gerry Kaplan(5), Ronald A. LeMahieu(5), Joseph Swistok(5), Barry A. Wolitzky(5), Karen Rowan(5), Francis A. Mennona(4), Sally C. Weatherford(4), Raymond Makofske(4), Joseph Michalewsky(4), Joseph Triscari(4), Tai-Nan Huang(4), R. W. Kierstead(4), Paul Levitan(4)