Christian J. Leumann

University of Bern — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

41h-index5.9kcitations287works0.32yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(192), Advanced biosensing and bioanalysis techniques(121), RNA and protein synthesis mechanisms(78), RNA Interference and Gene Delivery(34), Chemical Synthesis and Analysis(26)

Publications287 total

Author response for "Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i>/<i>Tec</i> double deficient X-linked agammaglobulinemia model"
2025
Author response for "Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i>/<i>Tec</i> double deficient X-linked agammaglobulinemia model"
2025
Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i> / <i>Tec</i> double deficient X-linked agammaglobulinemia model
RSC Chemical Biology·2025· 1 citedOpen Access
7′,5′-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy
Nucleic Acids Research·2021· 11 citedOpen Access
Swiss Science: Quo Vadis after Exclusion from the European Framework Program?
CHIMIA International Journal for Chemistry·2021· 1 citedOpen Access
Enzymatic synthesis of biphenyl-DNA oligonucleotides
Bioorganic & Medicinal Chemistry·2020· 10 citedOpen Access
Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease
Nucleic Acid Therapeutics·2019· 26 cited
NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance
Nucleic Acids Research·2019· 12 citedOpen Access
Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA
Beilstein Journal of Organic Chemistry·2019· 7 citedOpen Access
Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs
Methods in molecular biology·2019· 1 cited
Compatibility of 5-ethynyl-2′F-ANA UTP with <i>in vitro</i> selection for the generation of base-modified, nuclease resistant aptamers
Organic & Biomolecular Chemistry·2019· 15 citedOpen Access
6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations
Beilstein Journal of Organic Chemistry·2018· 12 citedOpen Access
tc-DNA/tc-DNA duplex
2018
Tc-DNA/DNA duplex
Biological Magnetic Resonance Bank·2018Open Access
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
Nucleic Acids Research·2017· 142 citedOpen Access
Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model
Bern Open Repository and Information System (University of Bern)·2017Open Access
What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?
Journal of the American Society for Mass Spectrometry·2017· 9 cited
Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model
Molecular Therapy — Nucleic Acids·2017· 73 citedOpen Access
Inside Back Cover: 2′β‐Fluoro‐Tricyclo Nucleic Acids (2′F‐tc‐ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation (Chem. Eur. J. 43/2017)
Chemistry - A European Journal·2017
Cover Picture: Enzymatic Synthesis of 7′,5′‐Bicyclo‐DNA Oligonucleotides (Chem. Asian J. 12/2017)
Chemistry - An Asian Journal·2017
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Frequent Co-authors

Christine Brotschi(7), Aurélie Goyenvalle(5), Albert Eschenmoser(5), Pascal A. Küpfer(4), Martin H. Bolli(4), Adrian Häberli(4), Graziella Griffith(3), Luis Garcı́a(3), Jürg Hunziker(3), Hans‐Jörg Roth(3), Markus Tarköy(3), Martin Egli(3), Samir EL Andaloussi(2), Kariem Ezzat(2), Branislav Dugovič(2), Stefan Schürch(2), Matthew J. A. Wood(2), Cyrille Vaillend(2), Kevan M. Shokat(2), Renee Sugasawara(2)