Hans‐Jörg Roth

Novartis (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index776citations22works1.52yr avg
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Research Topics

Chemical Synthesis and Analysis(11), RNA and protein synthesis mechanisms(5), Advanced biosensing and bioanalysis techniques(4), DNA and Nucleic Acid Chemistry(4), Carbohydrate Chemistry and Synthesis(4)

Publications22 total

Cooperative Free Energy: Induced Protein–Protein Interactions and Cooperative Solvation in Ternary Complexes
Journal of Chemical Theory and Computation·2025· 3 citedOpen Access
Cooperative Free Energy: Induced Protein–Protein Interactions and Cooperative Solvation in Ternary Complexes
2025Open Access
Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes
Journal of Medicinal Chemistry·2023· 50 citedOpen Access
Polar/apolar interfaces modulate the conformational behavior of cyclic peptides with impact on their passive membrane permeability
RSC Advances·2022· 20 citedOpen Access
Effect of Flexibility, Lipophilicity, and the Location of Polar Residues on the Passive Membrane Permeability of a Series of Cyclic Decapeptides
Journal of Medicinal Chemistry·2021· 48 citedOpen Access
Rationalization of the Membrane Permeability Differences in a Series of Analogue Cyclic Decapeptides
Journal of Chemical Information and Modeling·2018· 71 citedOpen Access
Back Cover: Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure (ChemMedChem 10/2016)
ChemMedChem·2016Open Access
Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure
ChemMedChem·2016· 71 cited
Pharmacokinetic Studies around the Mono‐ and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold
ChemMedChem·2016· 29 cited
CCDC 1451826: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Hydroxymethyl Salicylaldehyde Auxiliary for a Glycine-Dependent Amide-Forming Ligation
Organic Letters·2015· 8 cited
Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics
Organic Letters·2014· 6 cited
Combinatorial chemistry
Current Opinion in Chemical Biology·2005· 6 cited
Complex molecules: do they add value?
Current Opinion in Chemical Biology·2005· 75 cited
There is no such thing as ‘diversity’!
Current Opinion in Chemical Biology·2005· 31 cited
Quality Control in Combinatorial Chemistry:  Determinations of Amounts and Comparison of the “Purity” of LC−MS-Purified Samples by NMR, LC−UV and CLND
Journal of Combinatorial Chemistry·2005· 36 cited
Automated Parallel Synthesis of N-Alkylated-<i>α</i>-Amino Methyl Esters in Gram Quantities
CHIMIA International Journal for Chemistry·2003· 2 citedOpen Access
Alfeni Digesta
Duncker & Humblot eBooks·1999· 6 cited
Synthesis and Properties of 2′‐Deoxy‐1′,2′‐seco‐D‐ribosyl (5′ → 3′)oligonucleotides (= 1′,2′‐seco‐DNA) containing adenine and thymine
Helvetica Chimica Acta·1997· 24 cited
Warum Pentose‐ und nicht Hexose‐Nucleinsäuren??. Teil VI. ‘Homo‐DNS’: <sup>1</sup>H‐, <sup>13</sup>C‐, <sup>31</sup>P‐ und <sup>15</sup>N‐NMR‐spektroskopische Untersuchung von ddGlc(A‐A‐A‐A‐A‐T‐T‐T‐T‐T) in wässriger Lösung
Helvetica Chimica Acta·1993· 57 cited
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Frequent Co-authors

Marianne Fouché(11), Sereina Riniker(6), Markus Blatter(5), Michael Schäfer(4), Jörg Berghausen(4), Sandrine Desrayaud(4), Christian J. Leumann(3), Albert Eschenmoser(3), Philippe Piéchon(3), Ina Dix(3), Stephane Rodde(3), Jürg Hunziker(2), Markus Böhringer(2), Alfred Giger(2), Michael Göbel(2), Ravichandran Krishnan(2), Shuzhe Wang(2), Aimar Martin Garcia(2), Stephanie M. Linker(2), Christian Schellhaas(2)