Ethan S. Burstein

Acadia Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index4.0kcitations103works0.82yr avg
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Research Topics

Receptor Mechanisms and Signaling(48), Neuropeptides and Animal Physiology(17), Neuroscience and Neuropharmacology Research(16), Protein Kinase Regulation and GTPase Signaling(14), Neurotransmitter Receptor Influence on Behavior(10)

Publications103 total

Discovery of VU6052254: A Novel, Potent M <sub>1</sub> Positive Allosteric Modulator
ACS Chemical Neuroscience·2025Open Access
5-HT2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats
Behavioural Pharmacology·2025Open Access
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422
ACS Chemical Neuroscience·2025· 2 citedOpen Access
Imaging the 5-HT <sub>2C</sub> receptor with PET: Evaluation of 5-HT <sub>2C</sub> and 5-HT <sub>2A</sub> affinity of pimavanserin in the primate brain
Journal of Cerebral Blood Flow & Metabolism·2024· 1 citedOpen Access
Imaging the 5-HT2C receptor with PET: evaluation of 5-HT2C and 5-HT2A affinity of pimavanserin in the primate brain
Neuroscience Applied·2023· 1 citedOpen Access
Pimavanserin reverses multiple measures of anxiety in a rodent model of post-traumatic stress disorder
European Journal of Pharmacology·2022· 6 citedOpen Access
The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease
Alzheimer s & Dementia Translational Research & Clinical Interventions·2022· 6 citedOpen Access
Relevance of 5-HT2A Receptor Modulation of Pyramidal Cell Excitability for Dementia-Related Psychosis: Implications for Pharmacotherapy
CNS Drugs·2021· 23 citedOpen Access
Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF-Dependent Manner
ACS Chemical Neuroscience·2021· 8 cited
Pimavanserin, a 5HT<sub>2A</sub> receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease
Journal of Neurochemistry·2020· 25 citedOpen Access
Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats
Neuroscience Letters·2019· 9 cited
Should inverse agonists be defined by pharmacological mechanism or clinical effect?
CNS Spectrums·2019· 2 citedOpen Access
A subtype-specific neuropeptide FF receptor antagonist attenuates morphine and nicotine withdrawal syndrome in the rat
Neuroscience Letters·2018· 9 cited
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
ACS Chemical Neuroscience·2017· 27 citedOpen Access
Dronedarone Modulates M&lt;sub&gt;1&lt;/sub&gt; and M&lt;sub&gt;3&lt;/sub&gt; Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence
Pharmacology·2016· 4 cited
Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain
ACS Chemical Neuroscience·2016· 21 cited
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation
Journal of Medicinal Chemistry·2016· 19 citedOpen Access
Preclinical PET Neuroimaging of [<sup>11</sup>C]Bexarotene
Molecular Imaging·2016· 8 citedOpen Access
Reversal of morphine tolerance by a compound with NPFF receptor subtype-selective actions
Neuroscience Letters·2014· 24 citedOpen Access
Further characterization of the allosteric site of action of amiodarone at Gq‐linked muscarinic receptors (LB616)
The FASEB Journal·2014
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Frequent Co-authors

Mark R. Brann(21), Tracy A. Spalding(19), Roger Olsson(10), Erika A. Currier(9), Jian‐Nong Ma(9), Uli Hacksell(7), David M. Weiner(7), Hans H. Schiffer(7), Ian G. Macara(7), Jian-Nong Ma(6), Krista McFarland(5), Thomas Ott(5), Robert E. Davis(4), Norman Nash(4), Ali Tabatabaei(4), Luis R. Gardell(3), Jelveh Lameh(3), Andria L. Del Tredici(3), Fabrice Piu(3), Terri Messier(3)