Ali Tabatabaei

Vividion Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.0kcitations43works15.72yr avg
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Research Topics

Receptor Mechanisms and Signaling(9), Phosphodiesterase function and regulation(7), Neuroscience and Neuropharmacology Research(6), Cholinesterase and Neurodegenerative Diseases(6), Pharmacological Effects and Toxicity Studies(6)

Publications43 total

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Abstract 5719: Identification of EIK1004 (IMP1707), a CNS-penetrant, potent, and selective PARP1 inhibitor poised for testing in patients with HRD mutant tumors
Cancer Research·2025
Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Nature·2024· 1 citedOpen Access
Abstract IA003: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Molecular Cancer Therapeutics·2024
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Nature·2024· 89 cited
Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
Cancer Research·2024· 2 cited
Elastic Modulus Determination Based on Pressuremeter Tests and Standard Penetration Tests
2022
Abstract 6411: Discovery of covalent ligands to novel E3 ligases enables bispecific degraders with highly differentiated protein degradation across a broad range of targets
Cancer Research·2020· 1 cited
Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties
Bioorganic & Medicinal Chemistry Letters·2020· 7 citedOpen Access
Rapid identification of a novel phosphodiesterase 7B tracer for receptor occupancy studies using LC─MS/MS
Neurochemistry International·2020· 5 cited
Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat
Journal of Pharmacology and Experimental Therapeutics·2019· 10 citedOpen Access
Effect of phosphodiesterase (1B, 2A, 9A and 10A) inhibitors on central nervous system cyclic nucleotide levels in rats and mice
Neurochemistry International·2019· 8 cited
LC-MS/MS Rapid identification of a novel tracer for a subtype specific phosphodiesterase (PDE) with no known ligand
Drug Metabolism and Pharmacokinetics·2019
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties
Journal of Medicinal Chemistry·2018· 18 citedOpen Access
A surrogate analyte-based liquid chromatography-tandem mass spectrometry method for the determination of endogenous cyclic nucleotides in rat brain
Journal of Pharmaceutical and Biomedical Analysis·2017· 19 citedOpen Access
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
Journal of Medicinal Chemistry·2017· 55 citedOpen Access
Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
Journal of Medicinal Chemistry·2017· 52 citedOpen Access
CCDC 1539155: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Clinical Characteristics and Causality of Eye Lid Laceration in Iran
Oman Medical Journal·2013· 14 citedOpen Access
Discovery of potential antipsychotic agents possessing pro-cognitive properties
Naunyn-Schmiedeberg s Archives of Pharmacology·2011· 7 cited
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Frequent Co-authors

J. Guy Breitenbucher(7), Kristen A. Baltgalvis(6), Kent T. Symons(6), Shota Kikuchi(6), Ethan S. Burstein(6), Richard Barido(6), Kara Schmelzer(6), Roger Olsson(6), Kelsey N. Lamb(5), Chu-Chiao Wu(5), Melissa Hoffman(5), Aaron N. Snead(5), Xiaodan Song(5), Thomas Glaza(5), Jason C. Green(5), Betty Lam(5), Christie L. Eissler(5), Steffen M. Bernard(5), Jonathan Pollock(5), Martha K. Pastuszka(5)