Jacqueline M. Tremblay

Tufts University — United States

Medicine · Health Sciences

23h-index1.5kcitations55works4.72yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(13), Botulinum Toxin and Related Neurological Disorders(11), Viral gastroenteritis research and epidemiology(10), Toxin Mechanisms and Immunotoxins(10), Escherichia coli research studies(9)

Publications55 total

In-vivo-targeted gene delivery using adenovirus-antibody site-specific covalent conjugates
Molecular Therapy — Methods & Clinical Development·2025· 1 citedOpen Access
In vivo targeted gene delivery using Adenovirus-antibody molecular glue conjugates
2025Open Access
Affinity-tuned mesothelin CAR T cells demonstrate enhanced targeting specificity and reduced off-tumor toxicity
JCI Insight·2024· 13 citedOpen Access
Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies
PLoS ONE·2023· 5 citedOpen Access
Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies
2023Open Access
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Nature Communications·2023· 18 citedOpen Access
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
Cell Host & Microbe·2023· 116 citedOpen Access
Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917
PLoS Pathogens·2022· 17 citedOpen Access
Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes
Scientific Reports·2022· 18 citedOpen Access
Intramuscular delivery of formulated RNA encoding six linked single-domain antibodies is highly protective for exposures to three Botulinum neurotoxin serotypes
Research Square (Research Square)·2022Open Access
Engineered E. coli for the targeted deposition of therapeutic payloads to sites of disease
2022· 2 citedOpen Access
Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies
PLoS Pathogens·2022· 17 citedOpen Access
Engineered <i>E. coli</i> for the Targeted Deposition of Therapeutic Payloads to Sites of Disease
SSRN Electronic Journal·2022· 1 citedOpen Access
Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic <i>E. coli</i> Nissle 1917
2021Open Access
Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody
Journal of Controlled Release·2021· 14 citedOpen Access
Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium
International Journal for Parasitology·2021· 30 citedOpen Access
A heterohexameric protein consisting of six linked single-domain antibodies is highly protective for BoNT/A, BoNT/B and BoNT/E exposures
2021Open Access
Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function
Toxins·2020· 27 citedOpen Access
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins
Cell Reports·2020· 38 citedOpen Access
HIGHLY EFFICIENT SINGLE-DOMAIN ANTIBODY NEUTRALIZATION OF INTERLEUKIN-6, THE FACTOR AT THE EPICENTER OF CYTOKINE STORM IN ACUTELY ILL COVID-19 PATIENTS
Hepatology·2020
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Frequent Co-authors

Charles B. Shoemaker(37), Saul Tzipori(10), Michelle Debatis(9), Lynwood R. Yarbrough(8), Jean Mukherjee(8), David T. Curiel(8), George M. Helmkamp(7), Elena A. Kashentseva(7), Igor P. Dmitriev(7), Daniela Bedenice(5), John M. Leong(4), Clinton E. Leysath(4), Gillian Beamer(4), Robert Webb(4), Kwok Ho Lam(4), Celinia A. Ondeck(4), Patrick McNutt(4), Rongsheng Jin(4), Justyna J. Jaskiewicz(4), Marilyn D. Yoder(3)