Michel Detheux

Bone Therapeutics — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index8.2kcitations76works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(17), Neuropeptides and Animal Physiology(13), Pancreatic function and diabetes(11), Neurobiology and Insect Physiology Research(8), Adenosine and Purinergic Signaling(8)

Publications76 total

Multiplex IHC panel development for adenosine pathway markers and TIL in human cancer specimens
Annals of Oncology·2019
Abstract 3278: EOS100850 potently restores adenosine A2Areceptor-dependent suppression of T cell function in the adenosine rich tumor microenvironment
Cancer Research·2019· 2 cited
Abstract 3261: EOS100850, a non-brain penetrant highly selective A2Areceptor antagonist, uniquely maintains high potency within the adenosine rich tumor microenvironment
Cancer Research·2019· 6 cited
Abstract 3261: EOS100850, a non-brain penetrant highly selective A<sub>2A</sub>receptor antagonist, uniquely maintains high potency within the adenosine rich tumor microenvironment
Immunology·2019
Abstract 3278: EOS100850 potently restores adenosine A<sub>2A</sub>receptor-dependent suppression of T cell function in the adenosine rich tumor microenvironment
Clinical Research (Excluding Clinical Trials)·2019
Abstract LB-291: EOS100850, an insurmountable and non-brain penetrant A2A receptor antagonist, inhibits adenosine-mediated T cell suppression, demonstrates anti-tumor activity and exhibits best-in class characteristics
Cancer Research·2018· 9 cited
Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg
Cancer Research·2018· 5 cited
A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia
Science Signaling·2017· 89 cited
Abstract 1683: A novel adenosine A2A receptor antagonist optimized for high potency in adenosine-rich tumor microenvironment boosts antitumor immunity
Cancer Research·2017· 7 cited
Abstract 4612: Development and validation of a screening platform for the identification of novel immuno-oncology targets
Cancer Research·2017
iTeos Therapeutics
Human Vaccines & Immunotherapeutics·2017Open Access
Abstract B030: Development and validation of a phenotypic screening platform for the identification of novel immuno-oncology targets
Cancer Immunology Research·2016
Preclinical assessment of a novel small molecule inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2)
Journal for ImmunoTherapy of Cancer·2014· 5 citedOpen Access
Preclinical assessment of a novel small molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1)
Journal for ImmunoTherapy of Cancer·2014· 3 citedOpen Access
Invited Lecture: Le défi de la création d’une spin off belge pour développer des traitements innovants contre le cancer
DIAL (Catholic University of Leuven)·2014
Oxysterols direct immune cell migration via EBI2
Nature·2011· 460 cited
Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects
Biochemical Pharmacology·2010· 46 cited
Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5
Journal of Medicinal Chemistry·2010· 30 citedOpen Access
Significance of N-Terminal Proteolysis of CCL14a to Activity on the Chemokine Receptors CCR1 and CCR5 and the Human Cytomegalovirus-Encoded Chemokine Receptor US28
The Journal of Immunology·2009· 19 cited
Vasopressin-like peptide and its receptor function in an indirect diuretic signaling pathway in the red flour beetle
Insect Biochemistry and Molecular Biology·2008· 107 cited
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Frequent Co-authors

Marc Parmentier(23), Emile Van Schaftingen(13), Gilbert Vassart(12), Emmanuel Le Poul(9), Stéphane Brézillon(7), Vincent Dupriez(7), Vincent Lannoy(5), Karl E.O. Åkerman(5), Masato Kotani(4), Hendrica B. Oonk(4), Jalal Vakili(4), Emmanuel Burgeon(4), Herbert Torfs(4), Jeroen Poels(4), Tom Van Loy(4), Jozef Vanden Broeck(4), Sofie Struyf(3), Jo Van Damme(3), David Communi(3), Catherine Mollereau(3)