Michael P. DeNinno

Vertex Pharmaceuticals (United States) — United States

Chemistry · Physical Sciences

28h-index2.5kcitations73works0.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(20), Receptor Mechanisms and Signaling(14), Asymmetric Synthesis and Catalysis(9), Glycosylation and Glycoproteins Research(9), Synthetic Organic Chemistry Methods(8)

Publications73 total

Synthesis of Fused Bicyclic Piperidines: Potential Bioactive Templates for Medicinal Chemistry
The Journal of Organic Chemistry·2014· 20 cited
ChemInform Abstract: Discovery of Triazolopyrimidine‐Based PDE8B Inhibitors: Exceptionally Ligand‐Efficient and Lipophilic Ligand‐Efficient Compounds for the Treatment of Diabetes.
ChemInform·2013· 2 cited
From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
Bioorganic & Medicinal Chemistry Letters·2012· 21 citedOpen Access
Future directions in phosphodiesterase drug discovery
Bioorganic & Medicinal Chemistry Letters·2012· 31 citedOpen Access
Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
Bioorganic & Medicinal Chemistry Letters·2012· 26 citedOpen Access
CCDC 869332: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability
Bioorganic & Medicinal Chemistry Letters·2011· 25 citedOpen Access
Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response
Journal of Medicinal Chemistry·2011· 48 citedOpen Access
PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
PLoS ONE·2010· 68 citedOpen Access
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
Bioorganic & Medicinal Chemistry Letters·2009· 45 citedOpen Access
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor
Bioorganic & Medicinal Chemistry Letters·2006· 14 citedOpen Access
IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES
Drug Metabolism and Disposition·2005· 67 cited
Differing cardioprotective efficacy of the Na<sup>+</sup>/Ca<sup>2+</sup>exchanger inhibitors SEA0400 and KB-R7943
American Journal of Physiology-Heart and Circulatory Physiology·2003· 61 cited
3‘-Aminoadenosine-5‘-uronamides:  Discovery of the First Highly Selective Agonist at the Human Adenosine A <sub>3</sub> Receptor
Journal of Medicinal Chemistry·2002· 59 citedOpen Access
ChemInform Abstract: The Preparation and Intra‐ and Intermolecular Addition Reactions of Acyclic N‐Acylimines: Application to the Synthesis of (.+‐.)‐Sertraline.
ChemInform·2002
The Preparation and Intra- and Intermolecular Addition Reactions of Acyclic <i>N</i>-Acylimines:  Application to the Synthesis of (±)-Sertraline
The Journal of Organic Chemistry·2001· 31 cited
Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action
Journal of Lipid Research·1999· 71 citedOpen Access
Carbohydrate modifications in the spirostane cellobioside cholesterol absorption inhibitor series
Bioorganic & Medicinal Chemistry Letters·1998· 2 cited
Adenosine
Annual reports in medicinal chemistry·1998· 15 cited
ChemInform Abstract: Efficient Generation and Intramolecular Cyclization Reactions of Acyl Imines.
ChemInform·1997
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Frequent Co-authors

Samuel J. Danishefsky(13), John B. Etienne(11), Lee A. Morehouse(7), Charles E. Chandler(7), Robert Schoenleber(6), Lawrence M. Zaccaro(6), Cynthia Eller(6), Donald R. Britton(5), Robert G. MacKenzie(5), Karen E. Asin(5), John W. Kebabian(5), Peter A. McCarthy(5), Kimberly C. Duplantier(4), Richard J. Perner(4), Robert E. Zelle(4), Harold G. Selnick(3), F.W. Bangerter(3), Robert W. Wilkins(3), Heidi A. Woody(3), W. Ross Tracey(3)