Stephen T. Smale

Howard Hughes Medical Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

101h-index36.1kcitations353works27.72yr avg
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Research Topics

Genomics and Chromatin Dynamics(51), RNA and protein synthesis mechanisms(39), interferon and immune responses(39), RNA Research and Splicing(35), Immune Response and Inflammation(33)

Publications353 total

Relationship among Toll-like receptors, β2 adrenergic receptor, and mitogen-activated protein kinases in regulating <i>Il1b</i> transcription
The Journal of Immunology·2025
Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution
Nature Immunology·2025· 4 citedOpen Access
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters
Cell Discovery·2025· 12 citedOpen Access
Examining NF-κB genomic interactions by ChIP-seq and CUT&amp;Tag
2024Open Access
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway
Genes & Development·2024· 9 citedOpen Access
Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
Cell Reports·2024· 18 citedOpen Access
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation
Cell stem cell·2024· 27 citedOpen Access
The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
Immunity·2024· 46 citedOpen Access
IL-10 constrains sphingolipid metabolism to limit inflammation
Nature·2024· 187 citedOpen Access
Selective Regulation of a Defined Subset of Inflammatory and Immunoregulatory Genes by an NF-κB p50-IκBζ Pathway
2024· 1 citedOpen Access
Stepwise Neofunctionalization of the NF-κB Family Member c-Rel during Vertebrate Evolution
2024· 1 citedOpen Access
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation
2023· 1 citedOpen Access
IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation
2023· 8 citedOpen Access
Abstract 2325: IRF1 displays opposing tumor cell-intrinsic and -extrinsic roles in anti-tumor immunity
Cancer Research·2023
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology
Trends in Immunology·2023· 1 cited
Dr. Terri Grodzicker: leading<i>Genes &amp; Development</i>through 35 years of rapidly advancing molecular biology research
Genes & Development·2023Open Access
Kinetics of mRNA nuclear export regulate innate immune response gene expression
Nature Communications·2022· 16 citedOpen Access
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs
Genes & Development·2022· 8 citedOpen Access
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells
Genes & Development·2022· 16 citedOpen Access
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient
Trends in Immunology·2022· 1 cited
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Frequent Co-authors

Amanda G. Fisher(6), Bradley S. Cobb(5), Matthias Merkenschlager(4), Scott E. Plevy(3), David Baltimore(3), Michael Carey(3), K M Lo(3), Brandon J. Thomas(3), Hans D. Brightbill(2), Robert L. Modlin(2), Karen E. Brown(2), Ramin Javahery(2), Kiersten Lo(2), Vladimir Ramirez-Carrozzi(2), Dev Bhatt(2), Alexander Hoffmann(2), Arnulf Hertweck(2), Eric O’Connor(2), Elizabeth C. Thompson(2), Ann-Jay Tong(2)