Alexander Hoffmann

QB3 — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

80h-index23.4kcitations273works3.22yr avg
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Research Topics

NF-κB Signaling Pathways(105), Immune Response and Inflammation(100), Cytokine Signaling Pathways and Interactions(51), interferon and immune responses(36), T-cell and B-cell Immunology(25)

Publications271 total

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease
Frontiers in Immunology·2025Open Access
Topological measures on phylogenetic trees of the antibody repertoire reveal the underlying kinetics of B cell fate decisions 4844
The Journal of Immunology·2025Open Access
Macrophage reprogramming regulated by temporal and combinatorial signaling codes 2382
The Journal of Immunology·2025Open Access
A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease
2025Open Access
Reconstructing noisy gene regulation dynamics using extrinsic-noise-driven neural stochastic differential equations
PLoS Computational Biology·2025Open Access
A Molecular Characterization of Human General Transcription Factor IID
Digital Commons - RU (Rockefeller University)·2025Open Access
SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages
2025Open Access
Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging
Cell Reports·2025· 2 citedOpen Access
A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling
PLoS Computational Biology·2025· 1 citedOpen Access
Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL
Cell Death and Disease·2025Open Access
Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Pre-Viremic, Multi-Omic Immune Signatures of Cytomegalovirus Infection in Kidney Transplant Recipients
American Journal of Transplantation·2025Open Access
Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses
Nature Communications·2025· 6 citedOpen Access
Phased epigenetic fragility and stability accelerate the genetic evolution of B-cells
2025Open Access
IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself
2025· 1 citedOpen Access
Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion
Molecular Systems Biology·2025· 1 citedOpen Access
Protocol for the imputation of stimulus-induced single-cell gene expression trajectories from time-series scRNA-seq data
STAR Protocols·2025Open Access
Evolution of patients, injuries and outcome profiles in primary ACL reconstructions: Experience from an institutional ACL registry
Sports Orthopaedics and Traumatology·2025
A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling
2025Open Access
Macrophages maintain signaling fidelity in response to ligand mixtures
2025Open Access
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Frequent Co-authors

Robert G. Roeder(8), David Baltimore(6), Gourisankar Ghosh(5), Shannon L. Werner(5), Ellen L O'Dea(4), Soumen Basak(4), Jeffrey D. Kearns(4), Andre Levchenko(3), Masami Horikoshi(3), S.K. Burley(3), Candace Lynch(3), Martin Scott(2), Jean Lozach(2), Christopher Benner(2), Shankar Subramaniam(2), Michael G. Rosenfeld(2), Christopher K. Glass(2), Masataka Asagiri(2), Christine S. Cheng(2), Stephen T. Smale(2)