Christine Stürchler-Pierrat

Novartis (Switzerland) — Switzerland

Medicine · Health Sciences

20h-index5.3kcitations28works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(21), Prion Diseases and Protein Misfolding(7), Nuclear Receptors and Signaling(7), Genetics and Neurodevelopmental Disorders(4), Cholinesterase and Neurodegenerative Diseases(4)

Publications28 total

Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Nature Neuroscience·2004· 386 citedOpen Access
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
Proceedings of the National Academy of Sciences·2003· 325 citedOpen Access
Regional brain cytochrome oxidase activity in β-amyloid precursor protein transgenic mice with the swedish mutation
Neuroscience·2003· 30 cited
Progressive age-related impairment of cognitive behavior in APP23 transgenic mice
Neurobiology of Aging·2002· 185 cited
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
Brain Research·2002· 127 cited
Impaired hypoxic tolerance and altered protein binding of NADH in presymptomatic APP23 transgenic mice
Neuroscience·2002· 20 cited
Compromised Hemodynamic Response in Amyloid Precursor Protein Transgenic Mice
Journal of Neuroscience·2002· 101 citedOpen Access
Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis
Journal of Neuroscience·2002· 162 citedOpen Access
Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid
Journal of Neurochemistry·2002· 119 cited
The Evolution of Aβ Peptide Burden in the APP23 Transgenic Mice: Implications for Aβ Deposition in Alzheimer Disease
Molecular Medicine·2001· 91 citedOpen Access
Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains
Journal of Biological Chemistry·2001· 248 citedOpen Access
Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice
Research and perspectives in Alzheimer's disease·2001· 1 cited
Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model
Annals of the New York Academy of Sciences·2000· 168 cited
Inflammatory processes in the APP23 mouse model of Alzheimer's disease
Neurobiology of Aging·2000
Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease
Nature Neuroscience·2000· 257 cited
Mechanism and pathogenesis of cerebral amyloidosis in APP transgenic mice
Neurobiology of Aging·2000· 1 cited
Dystriphic neurites in plaque-like Aβdeposits in mice double transgenic for the APP 670671 mutation and the human four-repeat tau protein
Neurobiology of Aging·2000
Characterization of different transgenic mouse lines, overexpressing the FAD-linked human presenilin 1 CDNA
Neurobiology of Aging·2000
Transgenic Approaches to Model Alzheimer's Disease
Reviews in the Neurosciences·2000· 28 cited
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
Proceedings of the National Academy of Sciences·1999· 404 citedOpen Access
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Frequent Co-authors

Matthias Staufenbiel(24), Dorothée Abramowski(13), Bernd Sommer(13), Mathias Jucker(10), Karl‐Heinz Wiederhold(8), Michael E. Calhoun(7), Paolo Paganetti(5), Amie L. Phinney(5), A. Probst(4), Bruce A. Yankner(4), Markus Tolnay(4), Luca Bondolfi(4), Martina Stalder(3), David T. Winkler(3), Michelle Pfeifer(3), Peter H. Kelly(3), Claudia Mistl(2), Kurt Bürki(2), Pascal Frey(2), Zhuohua Zhang(2)