Zygmunt S. Derewenda

University of Virginia — United States

Materials Science · Physical Sciences

64h-index14.5kcitations240works2.82yr avg
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Research Topics

Enzyme Structure and Function(74), Protein Structure and Dynamics(50), Protein Kinase Regulation and GTPase Signaling(31), Enzyme Catalysis and Immobilization(26), Microtubule and mitosis dynamics(16)

Publications240 total

How protein kinase inhibitors bind to the hinge region of the target protein.
Structural Dynamics·2025Open Access
The occurrence of TrpCd1-H…O=Cbackbone hydrogen bonds in proteins
Structural Dynamics·2025Open Access
Differing Effects of Nonlinearity around the Proton Acceptor on CH··O and NH··O H-Bond Strength within Proteins
The Journal of Physical Chemistry B·2024· 4 cited
A structural role for tryptophan in proteins, and the ubiquitous Trp C <sup>δ1</sup> —H...O=C (backbone) hydrogen bond
Acta Crystallographica Section D Structural Biology·2024· 7 citedOpen Access
p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle
Frontiers in Physiology·2023· 2 citedOpen Access
C-H Groups as Donors in Hydrogen Bonds: A Historical Overview and Occurrence in Proteins and Nucleic Acids
International Journal of Molecular Sciences·2023· 47 citedOpen Access
C—H...O bonds involving Trp sidechain in protein structures
Acta Crystallographica Section A Foundations and Advances·2023Open Access
p90RSK2, a new MLCK, rescues contractility in myosin light chain kinase null smooth muscle
2023Open Access
<b>Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix</b>. By Howard Markel. W. W. Norton &amp; Co., 2021. Hardback, pp. 608. ISBN 978-1324002239. Price USD 30.00.
Acta Crystallographica Section D Structural Biology·2022
Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles
Molecular Biology of the Cell·2022· 3 citedOpen Access
On the centennials of the discoveries of the hydrogen bond and the structure of the water molecule: the short life and work of Eustace Jean Cuy (1897–1925)
Acta Crystallographica Section A Foundations and Advances·2021· 4 cited
The Structure of the Coiled-Coil Domain of Ndel1 and the Basis of Its Interaction with Lis1, the Causal Protein of Miller-Dieker Lissencephaly
UNC Libraries·2021Open Access
<scp>C─H</scp>⋯O hydrogen bonds in kinase‐inhibitor interfaces
IUBMB Life·2020· 23 citedOpen Access
Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain
Structure·2019· 65 citedOpen Access
Bacterial cellulose synthase outermembrane channel BcsC with terminal TPR repeat
2019· 2 cited
Protein crystallization by mutational surface engineering
Research & Reviews Journal of Material Sciences·2019
RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na <sup>+</sup> /H <sup>+</sup> exchanger
Science Signaling·2018· 18 citedOpen Access
The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab
Acta Crystallographica Section D Structural Biology·2018· 10 citedOpen Access
Adventures in cooperativity.
PubMed·2017· 1 cited
Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain
Acta Crystallographica Section D Structural Biology·2017· 9 cited
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Frequent Co-authors

Urszula Derewenda(27), Guy Dodson(11), E.J. Dodson(8), Lora Swenson(7), Zbigniew Dauter(6), Y. Devedjiev(6), A.M. Brzozowski(5), Yunyi Wei(5), David R. Cooper(4), Yau‐Huei Wei(4), Leo Brady(3), J.P. Turkenburg(3), David M. Lawson(3), Peter Sheffield(3), Laurence Serre(3), Myung Hee Kim(3), Robert Liddington(3), Birgitte Huge‐Jensen(2), Shamkant Patkar(2), L. Thim(2)