Lora Swenson

Vertex Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index4.1kcitations40works0.02yr avg
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Research Topics

Enzyme Catalysis and Immobilization(8), Enzyme Structure and Function(6), Microbial Metabolic Engineering and Bioproduction(5), Protein Kinase Regulation and GTPase Signaling(4), Enzyme Production and Characterization(4)

Publications40 total

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Journal of Medicinal Chemistry·2015· 87 cited
CCDC 994749: Experimental Crystal Structure Determination
The Cambridge Structural Database·2014Open Access
Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism
Structure·2010· 188 citedOpen Access
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Bioorganic & Medicinal Chemistry Letters·2009· 27 citedOpen Access
Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships
Journal of Medicinal Chemistry·2008· 222 citedOpen Access
Phenotypic Characterization of Resistant Val<sup>36</sup>Variants of Hepatitis C Virus NS3-4A Serine Protease
Antimicrobial Agents and Chemotherapy·2007· 94 citedOpen Access
Phenotypic and Structural Analyses of Hepatitis C Virus NS3 Protease Arg155 Variants
Journal of Biological Chemistry·2007· 88 citedOpen Access
The Structure of Dimeric ROCK I Reveals the Mechanism for
2006
The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity
Journal of Biological Chemistry·2005· 258 citedOpen Access
Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002
Journal of Biological Chemistry·2005· 187 citedOpen Access
Structure of the CoA transferase from pig heart to 1.7 Å resolution
Acta Crystallographica Section D Biological Crystallography·2004· 16 cited
Crystal Structures of <i>Escherichia coli</i> Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase
Antimicrobial Agents and Chemotherapy·2004· 156 citedOpen Access
The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain
Molecular Cell·2004· 495 citedOpen Access
STRUCTURE OF THE COA TRANSFERASE FROM PIG HEART TO 1.7 ANGSTROM RESOLUTION
Macromolecules·2004
SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART
2003
Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase
Journal of Biological Chemistry·2002· 192 citedOpen Access
Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export
Journal of Biological Chemistry·2002· 131 citedOpen Access
Crystal Structure of MAPKAP2
2002
Crystal structure of calcium‐free human sorcin: A member of the penta‐EF‐hand protein family
Protein Science·2001· 52 citedOpen Access
Structure of GSK3beta reveals a primed phosphorylation mechanism.
Nature Structural Biology·2001· 382 cited
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Frequent Co-authors

Zygmunt S. Derewenda(16), Urszula Derewenda(11), Yunyi Wei(9), Judith A. Lippke(5), Koto Hayakawa(5), Yau‐Huei Wei(5), Joyce T. Coll(4), Rolf D. Joerger(4), Ruth Green(4), James Black(3), Kumkum Saxena(3), Ernst ter Haar(3), Marc Jacobs(3), Steven F. Bellon(3), Mark Fleming(3), Paul S. Charifson(3), Michael J. Haas(3), Abbie M. Coros(3), William T. Wolodko(3), M.E. Fraser(3)