Alexander Traxl

Austrian Institute of Technology — Austria

Medicine · Health Sciences

11h-index405citations25works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(16), Pharmacological Effects and Toxicity Studies(12), Medical Imaging Techniques and Applications(6), Radiopharmaceutical Chemistry and Applications(6), Pancreatic and Hepatic Oncology Research(5)

Publications22 total

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice
Pharmaceutics·2021· 10 citedOpen Access
Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice
European Journal of Pharmaceutical Sciences·2021· 12 citedOpen Access
Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [<sup>11</sup>C]Tariquidar and PET in Humans and Mice
Molecular Pharmaceutics·2019· 22 citedOpen Access
Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET Study
Journal of Nuclear Medicine·2019· 38 citedOpen Access
Inhibition of ABCB1 and ABCG2 at the Mouse Blood–Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [<sup>11</sup>C]erlotinib
Molecular Pharmaceutics·2019· 23 cited
Investigation of Transporter-Mediated Drug-Drug Interactions Using PET/MRI
2018· 1 cited
Effect of Rifampicin on the Distribution of [<sup>11</sup>C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice
Molecular Pharmaceutics·2018· 23 cited
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
Molecular Imaging and Biology·2018· 22 citedOpen Access
Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
European Journal of Pharmaceutical Sciences·2018· 4 citedOpen Access
Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography
Clinical Pharmacology & Therapeutics·2017· 55 citedOpen Access
Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [11C]erlotinib and Positron Emission Tomography
Drug Metabolism and Disposition·2017· 11 cited
[ 11 C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice
Nuclear Medicine and Biology·2017· 8 cited
Apport de l’imagerie TEP pour l’étude et de la neuropharmacocinétique de l’erlotinib et l’évaluation de stratégies d’optimisation de sa distribution cérébrale
Médecine Nucléaire·2017
A Prediction Method for P-glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier From Blood Concentration–Time Profiles, Validated With PET Data
Journal of Pharmaceutical Sciences·2017· 5 citedOpen Access
Synthesis and preclinical characterization of 1-(6′-deoxy-6′-[18F]fluoro-β-d-allofuranosyl)-2-nitroimidazole (β-6′-[18F]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia
Bioorganic & Medicinal Chemistry·2016· 14 cited
Strategies to Inhibit ABCB1- and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood–Brain Barrier: A PET Study on Nonhuman Primates
Journal of Nuclear Medicine·2016· 50 citedOpen Access
High dose erlotinib as an alternative to elacridar for the combined inhibition of ABCB1 and ABCG2 at the blood-brain barrier: an 11C-erlotinib PET study in nonhuman primates
2016
Breast Cancer Resistance Protein and P-Glycoprotein Influence In Vivo Disposition of <sup>11</sup>C-Erlotinib
Journal of Nuclear Medicine·2015· 57 citedOpen Access
Factors Governing P-Glycoprotein-Mediated Drug–Drug Interactions at the Blood–Brain Barrier Measured with Positron Emission Tomography
Molecular Pharmaceutics·2015· 45 citedOpen Access
In vitro uptake experiments in different cancer cell lines using [11C]erlotinib
2015
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Frequent Co-authors

Thomas Wanek(20), Oliver Langer(20), Severin Mairinger(16), Johann Stanek(12), Claudia Kuntner(12), Michael Sauberer(10), Thomas Filip(9), Martin Bauer(5), Nicolas Tournier(5), Walter Jäger(4), Markus Zeitlinger(4), Markus Müller(3), Akihiro MATSUDA(3), Beatrix Wulkersdorfer(3), C. Philippe(3), Stefan Poschner(3), Marcus Hacker(3), Michaël Soussan(3), Jens Pahnke(3), Viktoria Zoufal(3)