Severin Mairinger

Medical University of Vienna — Austria

Medicine · Health Sciences

21h-index1.2kcitations92works1.82yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(61), Pharmacological Effects and Toxicity Studies(35), Radiopharmaceutical Chemistry and Applications(20), Medical Imaging Techniques and Applications(12), Amino Acid Enzymes and Metabolism(9)

Publications86 total

In vivo evidence of functional OATP2B1 activity in human skeletal muscle using [11C]erlotinib PET
European Journal of Pharmaceutical Sciences·2026Open Access
Evaluating methodological constraints in PET imaging of neuropeptide Y2 receptors with N-[11C]-methyl-(R)-JNJ-31020028 in brains of C57BL/6J mice
EJNMMI Radiopharmacy and Chemistry·2025Open Access
Imaging P-glycoprotein function at the blood-brain barrier in drug-resistant epilepsy using [11C]metoclopramide
European Journal of Nuclear Medicine and Molecular Imaging·2025· 1 cited
Evaluation of dose linearity in the systemic availability and pharmacokinetics of topically administered diclofenac: A 14C-microdosing study in healthy volunteers
Drug Metabolism and Disposition·2025Open Access
Functional MRP1 activity in human skeletal muscle
British Journal of Pharmacology·2025Open Access
Effect of probenecid on the whole-body disposition of 6-bromo-7-[11C]methylpurine in humans assessed with long axial field-of-view PET/CT
European Journal of Nuclear Medicine and Molecular Imaging·2025· 1 citedOpen Access
[11C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients
Fluids and Barriers of the CNS·2024· 5 citedOpen Access
First-in-human evaluation of 6-bromo-7-[11C]methylpurine, a PET tracer for assessing the function of multidrug resistance-associated proteins in different tissues
European Journal of Nuclear Medicine and Molecular Imaging·2024· 2 citedOpen Access
St. John's wort extract with a high hyperforin content does not induce P‐glycoprotein activity at the human blood–brain barrier
Clinical and Translational Science·2024· 6 citedOpen Access
Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates
EJNMMI Radiopharmacy and Chemistry·2024· 2 citedOpen Access
Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities
Pharmaceuticals·2024· 2 citedOpen Access
Performance and Sensitivity of [<sup>99m</sup>Tc]Tc-sestamibi Compared with Positron Emission Tomography Radiotracers to Measure P-glycoprotein Function in the Kidneys and Liver
Molecular Pharmaceutics·2024· 3 citedOpen Access
Multi-organ comparison and quantification parameters of [18F]THK-5317 uptake in preclinical mouse models of tau pathology
Frontiers in Physics·2023Open Access
Dissimilar Effect of P-Glycoprotein and Breast Cancer Resistance Protein Inhibition on the Distribution of Erlotinib to the Retina and Brain in Humans and Mice
Molecular Pharmaceutics·2023· 2 citedOpen Access
[ <sup>11</sup> C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier
Journal of Cerebral Blood Flow & Metabolism·2023· 6 citedOpen Access
Impact of a moderate decrease in the abundance of P-glycoprotein at the blood–brain barrier on the brain distribution of model P-glycoprotein substrates
Intrinsic Activity·2023
Effect of budesonide on pulmonary activity of multidrug resistance-associated protein 1 assessed with PET imaging in rats
European Journal of Pharmaceutical Sciences·2023· 4 citedOpen Access
Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs
Antimicrobial Agents and Chemotherapy·2023· 4 citedOpen Access
Influence of P-glycoprotein on pulmonary disposition of the model substrate [11C]metoclopramide assessed by PET imaging in rats
European Journal of Pharmaceutical Sciences·2023· 8 citedOpen Access
Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds
Nuclear Medicine and Biology·2022· 6 cited
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Frequent Co-authors

Thomas Wanek(46), Oliver Langer(45), Johann Stanek(37), Claudia Kuntner(27), Thomas Filip(24), Michael Sauberer(21), Markus Müller(14), Alexander Traxl(11), Irene Hernández-Lozano(11), Thomas Erker(10), Wolfgang Löscher(9), Jens P. Bankstahl(8), Marion Bankstahl(8), Jens Pahnke(8), Nicolas Tournier(7), Viktoria Zoufal(7), Florian F. Bauer(6), Markus Krohn(6), Carsten Ehrhardt(6), Martin Bauer(5)