Jenny Sandmark

AstraZeneca (Brazil) — Brazil

Materials Science · Physical Sciences

13h-index483citations28works0.52yr avg
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Research Topics

Enzyme Structure and Function(5), Biochemical and Molecular Research(5), Protein Kinase Regulation and GTPase Signaling(3), Carbohydrate Chemistry and Synthesis(3), Signaling Pathways in Disease(3)

Publications28 total

The Rise and Fall of SARM1 Base-Exchange Inhibitors
2025
Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling
Journal of Medicinal Chemistry·2025· 1 cited
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism
Journal of Medicinal Chemistry·2023· 24 citedOpen Access
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function
Journal of Biological Chemistry·2020· 13 citedOpen Access
Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands
Communications Biology·2019· 38 citedOpen Access
Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Science Advances·2019· 35 citedOpen Access
Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A<sub>2</sub> Type X (sPLA<sub>2</sub>-X) Inhibitors
ACS Medicinal Chemistry Letters·2018· 12 citedOpen Access
Design of Selective sPLA<sub>2</sub>-X Inhibitor (−)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1<i>H</i>-indol-1-yl]pyridine-2-yl}propanoic Acid
ACS Medicinal Chemistry Letters·2018· 8 citedOpen Access
Neurturin-GFRa2-RET extracellular complex
2018
Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling
Journal of Biological Chemistry·2018· 35 citedOpen Access
human Neurturin (97-197)
2017
Ligand-receptor complex.
2016
Discovery of AZD2716: A Novel Secreted Phospholipase A<sub>2</sub> (sPLA<sub>2</sub>) Inhibitor for the Treatment of Coronary Artery Disease
ACS Medicinal Chemistry Letters·2016· 40 citedOpen Access
Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design
PLoS ONE·2015· 37 citedOpen Access
Human FXIa in complex with small molecule inhibitors.
2014
Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening
Bioorganic & Medicinal Chemistry Letters·2014· 19 citedOpen Access
Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design
2014
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
2013
Conserved and Nonconserved Residues in the Substrate Binding Site of 7,8-Diaminopelargonic Acid Synthase from <i>Escherichia coli</i> Are Essential for Catalysis
Biochemistry·2004· 18 cited
Enzymatic mechanisms in biotin synthesis: vitamin B6 catalysis and phosphoryl transfer
Figshare·2003Open Access
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Frequent Co-authors

G. Schneider(8), Robert Roth(8), Linda Öster(6), Tomas Åkerud(6), Hans‐Georg Beisel(5), Janna M. Bigalke(5), Katharine J. Gibson(4), Ylva Lindqvist(4), Laurent Knerr(4), Birgitta Rosengren(4), Ola Fjellström(4), Wolfgang Knecht(4), Anna Tigerström(4), Fabrizio Giordanetto(3), Daniel Pettersen(3), Peter Nordberg(3), Mikael Dahlström(3), Nidhal Selmi(3), Eva Hurt‐Camejo(3), Emma Evertsson(3)